β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Hypertrophic cardiomyopathy (HCM) leads to hyper-contractility of the heart and is often caused by mutations in human β-cardiac myosin. Here authors show that four separate β-cardiac myosin mutations can modulate myosin activity by disrupting intramolecular interactions.

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Autores principales:	Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, Dan Song, Kristina B. Kooiker, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63d16de0a0bc403b814ee96f47af11ce
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spelling	oai:doaj.org-article:63d16de0a0bc403b814ee96f47af11ce2021-12-02T17:33:22Zβ-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity10.1038/s41467-019-10555-92041-1723https://doaj.org/article/63d16de0a0bc403b814ee96f47af11ce2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10555-9https://doaj.org/toc/2041-1723Hypertrophic cardiomyopathy (HCM) leads to hyper-contractility of the heart and is often caused by mutations in human β-cardiac myosin. Here authors show that four separate β-cardiac myosin mutations can modulate myosin activity by disrupting intramolecular interactions.Arjun S. AdhikariDarshan V. TrivediSaswata S. SarkarDan SongKristina B. KooikerDaniel BernsteinJames A. SpudichKathleen M. RuppelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arjun S. Adhikari Darshan V. Trivedi Saswata S. Sarkar Dan Song Kristina B. Kooiker Daniel Bernstein James A. Spudich Kathleen M. Ruppel β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
description	Hypertrophic cardiomyopathy (HCM) leads to hyper-contractility of the heart and is often caused by mutations in human β-cardiac myosin. Here authors show that four separate β-cardiac myosin mutations can modulate myosin activity by disrupting intramolecular interactions.
format	article
author	Arjun S. Adhikari Darshan V. Trivedi Saswata S. Sarkar Dan Song Kristina B. Kooiker Daniel Bernstein James A. Spudich Kathleen M. Ruppel
author_facet	Arjun S. Adhikari Darshan V. Trivedi Saswata S. Sarkar Dan Song Kristina B. Kooiker Daniel Bernstein James A. Spudich Kathleen M. Ruppel
author_sort	Arjun S. Adhikari
title	β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
title_short	β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
title_full	β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
title_fullStr	β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
title_full_unstemmed	β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
title_sort	β-cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/63d16de0a0bc403b814ee96f47af11ce
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

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