Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women

Abstract Adolescent drinking is associated with higher risks of proliferative benign breast disease (BBD) and invasive breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber)...

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Autores principales:	Catherine S. Berkey, Rulla M. Tamimi, Walter C. Willett, Bernard Rosner, Martha Hickey, Adetunji T. Toriola, A. Lindsay Frazier, Graham A. Colditz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/63d68b5bdfb44cb8971a102062b4c917
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spelling	oai:doaj.org-article:63d68b5bdfb44cb8971a102062b4c9172021-12-02T16:19:49ZAdolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women10.1038/s41523-020-00206-42374-4677https://doaj.org/article/63d68b5bdfb44cb8971a102062b4c9172020-11-01T00:00:00Zhttps://doi.org/10.1038/s41523-020-00206-4https://doaj.org/toc/2374-4677Abstract Adolescent drinking is associated with higher risks of proliferative benign breast disease (BBD) and invasive breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.Catherine S. BerkeyRulla M. TamimiWalter C. WillettBernard RosnerMartha HickeyAdetunji T. ToriolaA. Lindsay FrazierGraham A. ColditzNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 6, Iss 1, Pp 1-5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Catherine S. Berkey Rulla M. Tamimi Walter C. Willett Bernard Rosner Martha Hickey Adetunji T. Toriola A. Lindsay Frazier Graham A. Colditz Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
description	Abstract Adolescent drinking is associated with higher risks of proliferative benign breast disease (BBD) and invasive breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. We hypothesize that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol. A prospective cohort of 9031 females, 9–15 years at baseline, completed questionnaires in 1996–2001, 2003, 2005, 2007, 2010, 2013, and 2014. Participants completed food frequency questionnaires in 1996–2001. In 2005, participants (>=18 years) began reporting biopsy-confirmed BBD (N = 173 cases). Multivariable logistic regression estimated associations between BBD and cross-classified intakes (14–17 years) of alcohol and peanut butter/nuts (separately, total dietary fiber). Only 19% of participants drank in high school; drinking was associated with elevated BBD risk (OR = 1.75, 95% CI: 1.20–2.56; p = 0.004) compared to nondrinkers. Participants consuming any nuts/butter had lower BBD risk (OR = 0.64, 95% CI: 0.45–0.90; p = 0.01) compared to those consuming none. Participants in top 75% fiber intake had lower risk (OR = 0.57, 95% CI: 0.40–0.81; p = 0.002) compared to bottom quartile. Testing our hypothesis that consuming nuts/butter mitigates the elevated alcohol risk, analyzing alcohol and nuts combined found that those who consumed both had lower risk (RR = 0.47, 95% CI: 0.24–0.89; p = 0.02) compared to drinkers eating no nuts. Our analysis of alcohol and fiber together did not demonstrate risk mitigation by fiber. For high school females who drink, their BBD risk may be attenuated by consuming nuts. Due to modest numbers, future studies need to replicate our findings in adolescent/adult females. However, high school students may be encouraged to eat nuts and fiber, and to avoid alcohol, to reduce risk of BBD and for general health benefits.
format	article
author	Catherine S. Berkey Rulla M. Tamimi Walter C. Willett Bernard Rosner Martha Hickey Adetunji T. Toriola A. Lindsay Frazier Graham A. Colditz
author_facet	Catherine S. Berkey Rulla M. Tamimi Walter C. Willett Bernard Rosner Martha Hickey Adetunji T. Toriola A. Lindsay Frazier Graham A. Colditz
author_sort	Catherine S. Berkey
title	Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
title_short	Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
title_full	Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
title_fullStr	Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
title_full_unstemmed	Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
title_sort	adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63d68b5bdfb44cb8971a102062b4c917
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Adolescent alcohol, nuts, and fiber: combined effects on benign breast disease risk in young women

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