Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis

Abstract Background Bleeding, hematoma, edema, wound infection, and scar formation are the common problems linked with hypospadias reconstruction. Hormone treatment is recommended before surgical treatment to improve intraoperative circumstances. However, no meta-analysis has explored the effectiven...

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Autores principales:	Gozali Sembiring, Yacobda Sigumonrong
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Hypospadias Testosterone Urethroplasty Pediatrics RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/63d82f61639a475b9c6b36b77c98d3d7
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spelling	oai:doaj.org-article:63d82f61639a475b9c6b36b77c98d3d72021-11-14T12:24:42ZEfficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis10.1186/s43159-021-00117-42090-5394https://doaj.org/article/63d82f61639a475b9c6b36b77c98d3d72021-11-01T00:00:00Zhttps://doi.org/10.1186/s43159-021-00117-4https://doaj.org/toc/2090-5394Abstract Background Bleeding, hematoma, edema, wound infection, and scar formation are the common problems linked with hypospadias reconstruction. Hormone treatment is recommended before surgical treatment to improve intraoperative circumstances. However, no meta-analysis has explored the effectiveness and side effects of testosterone treatment before surgery in hypospadias. Main body of the abstract The purpose of this paperwork is to evaluate the impact of preoperative testosterone treatment in hypospadias based on clinical data from published trials. This study searched MEDLINE, Science Direct, and the Cochrane Library without regard to year. However, only English journals were included, with a manual search using the Preferred Reporting Items for Systematic Reviews and Meta-analysis of Observational Studies in Epidemiology Guidelines supplementing the search. In this meta-analysis, five papers were considered. Two of these investigations were multicenter randomized clinical trials. Two of the studies were prospective, with a median follow-up of varying lengths. A retrospective investigation was conducted. There were 585 patients in all that took part in this trial. After surgery, the complication rate was measured in both the intervention and control groups, including meatal stenosis, fistula, glans dehiscence, scarring, reoperation rate, urethral diverticulum, fine pubic hair, and sexual precocity. The only significant difference between the intervention and control groups was that the intervention group had a decreased frequency of glans dehiscence following surgery (OR 0.40 with the 95% CI of 0.17 until 0.97). Conclusions This study discovered that a patient who got testosterone before surgery had a considerably decreased complication risk for glandular dehiscence. Reoperation rate, urethral-cutaneous fistula, meatal stenosis, and penile scarring in children with hypospadias, on the other hand, revealed no significant difference in the testosterone-treated group against the control group.Gozali SembiringYacobda SigumonrongSpringerOpenarticleHypospadiasTestosteroneUrethroplastyPediatricsRJ1-570SurgeryRD1-811ENAnnals of Pediatric Surgery, Vol 17, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypospadias Testosterone Urethroplasty Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	Hypospadias Testosterone Urethroplasty Pediatrics RJ1-570 Surgery RD1-811 Gozali Sembiring Yacobda Sigumonrong Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
description	Abstract Background Bleeding, hematoma, edema, wound infection, and scar formation are the common problems linked with hypospadias reconstruction. Hormone treatment is recommended before surgical treatment to improve intraoperative circumstances. However, no meta-analysis has explored the effectiveness and side effects of testosterone treatment before surgery in hypospadias. Main body of the abstract The purpose of this paperwork is to evaluate the impact of preoperative testosterone treatment in hypospadias based on clinical data from published trials. This study searched MEDLINE, Science Direct, and the Cochrane Library without regard to year. However, only English journals were included, with a manual search using the Preferred Reporting Items for Systematic Reviews and Meta-analysis of Observational Studies in Epidemiology Guidelines supplementing the search. In this meta-analysis, five papers were considered. Two of these investigations were multicenter randomized clinical trials. Two of the studies were prospective, with a median follow-up of varying lengths. A retrospective investigation was conducted. There were 585 patients in all that took part in this trial. After surgery, the complication rate was measured in both the intervention and control groups, including meatal stenosis, fistula, glans dehiscence, scarring, reoperation rate, urethral diverticulum, fine pubic hair, and sexual precocity. The only significant difference between the intervention and control groups was that the intervention group had a decreased frequency of glans dehiscence following surgery (OR 0.40 with the 95% CI of 0.17 until 0.97). Conclusions This study discovered that a patient who got testosterone before surgery had a considerably decreased complication risk for glandular dehiscence. Reoperation rate, urethral-cutaneous fistula, meatal stenosis, and penile scarring in children with hypospadias, on the other hand, revealed no significant difference in the testosterone-treated group against the control group.
format	article
author	Gozali Sembiring Yacobda Sigumonrong
author_facet	Gozali Sembiring Yacobda Sigumonrong
author_sort	Gozali Sembiring
title	Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
title_short	Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
title_full	Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
title_fullStr	Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
title_full_unstemmed	Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
title_sort	efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/63d82f61639a475b9c6b36b77c98d3d7
work_keys_str_mv	AT gozalisembiring efficacyofpreoperativetestosteronetherapyinhypospadiasasystematicreviewandmetaanalysis AT yacobdasigumonrong efficacyofpreoperativetestosteronetherapyinhypospadiasasystematicreviewandmetaanalysis
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Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis

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