Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to Ju...

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Autores principales:	Larissa PAVANELLO, Fátima G. FARHAT, Rafaela P. CARVALHO, Hellen T. GREGÓRIO
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2021
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/63d9deb03b604de8b4e5081ba9a6063d
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spelling	oai:doaj.org-article:63d9deb03b604de8b4e5081ba9a6063d2021-11-28T02:42:49ZClinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study10.30968/rbfhss.2021.122.05732179-59242316-7750https://doaj.org/article/63d9deb03b604de8b4e5081ba9a6063d2021-06-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/573https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety. Larissa PAVANELLOFátima G. FARHATRafaela P. CARVALHOHellen T. GREGÓRIOSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
description	Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety.
format	article
author	Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO
author_facet	Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO
author_sort	Larissa PAVANELLO
title	Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
title_short	Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
title_full	Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
title_fullStr	Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
title_full_unstemmed	Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
title_sort	clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2021
url	https://doaj.org/article/63d9deb03b604de8b4e5081ba9a6063d
work_keys_str_mv	AT larissapavanello clinicallyrelevantdruginteractionsinvolvingantimicrobialsinageneralhospitalacrosssectionalstudy AT fatimagfarhat clinicallyrelevantdruginteractionsinvolvingantimicrobialsinageneralhospitalacrosssectionalstudy AT rafaelapcarvalho clinicallyrelevantdruginteractionsinvolvingantimicrobialsinageneralhospitalacrosssectionalstudy AT hellentgregorio clinicallyrelevantdruginteractionsinvolvingantimicrobialsinageneralhospitalacrosssectionalstudy
_version_	1718408442848215040

Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

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