Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals

While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first...

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Autores principales:	Claudia Vanetti, Daria Trabattoni, Marta Stracuzzi, Antonella Amendola, Clara Fappani, Valeria Rubinacci, Claudio Fenizia, Laura Gianolio, Mara Biasin, Anna Dighera, Irma Saulle, Elisabetta Tanzi, Gianvincenzo Zuccotti, Mario Clerici, Vania Giacomet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV COVID-19 SARS-CoV-2 IL-10 immune response children Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/63dddbe732ad41f7974248a3deab0e93
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spelling	oai:doaj.org-article:63dddbe732ad41f7974248a3deab0e932021-11-25T17:12:35ZImmunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals10.3390/cells101131872073-4409https://doaj.org/article/63dddbe732ad41f7974248a3deab0e932021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3187https://doaj.org/toc/2073-4409While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first wave of COVID-19 pandemic. SARS-CoV-2 RNA, virus-specific antibodies, as well as the expression of factors involved in the anti-viral immune response were analyzed. Moreover, we set up an in vitro coinfection assay to study the mechanisms correlated to the coinfection process. Our results did not show any increased risk of severe COVID-19 in HIV-positive young individuals. In those subjects who contracted SARS-CoV-2 infection, an increase in IL-10 expression and production was observed. Furthermore, in the in vitro coinfection assay, we revealed a reduction in SARS-CoV-2 replication associated to an upregulation of IL-10. We speculate that IL-10 could play a crucial role in the course of SARS-CoV-2 infection in HIV-positive individuals. These results might help defining clinical management of HIV/SARS-CoV-2 co-infected young individuals, or putative indications for vaccination schedules in this population.Claudia VanettiDaria TrabattoniMarta StracuzziAntonella AmendolaClara FappaniValeria RubinacciClaudio FeniziaLaura GianolioMara BiasinAnna DigheraIrma SaulleElisabetta TanziGianvincenzo ZuccottiMario ClericiVania GiacometMDPI AGarticleHIVCOVID-19SARS-CoV-2IL-10immune responsechildrenBiology (General)QH301-705.5ENCells, Vol 10, Iss 3187, p 3187 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV COVID-19 SARS-CoV-2 IL-10 immune response children Biology (General) QH301-705.5
spellingShingle	HIV COVID-19 SARS-CoV-2 IL-10 immune response children Biology (General) QH301-705.5 Claudia Vanetti Daria Trabattoni Marta Stracuzzi Antonella Amendola Clara Fappani Valeria Rubinacci Claudio Fenizia Laura Gianolio Mara Biasin Anna Dighera Irma Saulle Elisabetta Tanzi Gianvincenzo Zuccotti Mario Clerici Vania Giacomet Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
description	While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first wave of COVID-19 pandemic. SARS-CoV-2 RNA, virus-specific antibodies, as well as the expression of factors involved in the anti-viral immune response were analyzed. Moreover, we set up an in vitro coinfection assay to study the mechanisms correlated to the coinfection process. Our results did not show any increased risk of severe COVID-19 in HIV-positive young individuals. In those subjects who contracted SARS-CoV-2 infection, an increase in IL-10 expression and production was observed. Furthermore, in the in vitro coinfection assay, we revealed a reduction in SARS-CoV-2 replication associated to an upregulation of IL-10. We speculate that IL-10 could play a crucial role in the course of SARS-CoV-2 infection in HIV-positive individuals. These results might help defining clinical management of HIV/SARS-CoV-2 co-infected young individuals, or putative indications for vaccination schedules in this population.
format	article
author	Claudia Vanetti Daria Trabattoni Marta Stracuzzi Antonella Amendola Clara Fappani Valeria Rubinacci Claudio Fenizia Laura Gianolio Mara Biasin Anna Dighera Irma Saulle Elisabetta Tanzi Gianvincenzo Zuccotti Mario Clerici Vania Giacomet
author_facet	Claudia Vanetti Daria Trabattoni Marta Stracuzzi Antonella Amendola Clara Fappani Valeria Rubinacci Claudio Fenizia Laura Gianolio Mara Biasin Anna Dighera Irma Saulle Elisabetta Tanzi Gianvincenzo Zuccotti Mario Clerici Vania Giacomet
author_sort	Claudia Vanetti
title	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
title_short	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
title_full	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
title_fullStr	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
title_full_unstemmed	Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals
title_sort	immunological characterization of hiv and sars-cov-2 coinfected young individuals
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63dddbe732ad41f7974248a3deab0e93
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Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals

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