LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION

Abstract. Local immune responses of mucous membranes of an organism are the first and most significant barriers preventing many virus infections, including influenza. The barrier against influenza infection is the mucosalassociated lymphoid tissue of the upper airways. It is considered, that nasopha...

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Autores principales:	G. D. Petukhova, A. N. Naikhin, I. B. Barantseva, S. A. Donina, T. V. Chirkova, E. P. Grigorieva, L. G. Rudenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	local immune responses influenza infection vaccination Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/63deaaca60964ef5ae44a0c32db69f69
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spelling	oai:doaj.org-article:63deaaca60964ef5ae44a0c32db69f692021-11-18T08:03:42ZLOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION1563-06252313-741X10.15789/1563-0625-2006-4-511-516https://doaj.org/article/63deaaca60964ef5ae44a0c32db69f692014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/475https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Local immune responses of mucous membranes of an organism are the first and most significant barriers preventing many virus infections, including influenza. The barrier against influenza infection is the mucosalassociated lymphoid tissue of the upper airways. It is considered, that nasopharyngeal-associated lymphoid tissue (NALT) in rodents is an equivalent of lymphoid tissue in human Waldeyer’s ring. Present work is the first attempt to analyze and compare the development of cellular and antibody immune responses in NALT in a mouse model of experimental influenza infection using a pathogenic influenza A (H1N1) virus and an attenuated reassorted (2/6 genetic formula) live influenza A (H1N1) vaccine.It was shown, that the vaccine strain inherits the ability to induce high-grade local antibody responses like as the virulent parental strain. However, the vaccine strain is inferior to virulent parental strain in capacity to stimulate production of circulating antibodies. Both parental and Р 2/6 strains are equally able to induce lymphoproliferative immune response in NALT lymphocytes. The attenuated reassortant virus is able to stimulate proliferation of Th (CD4+), B-cells (CD19+) and CTL (CD8+) in NALT. As shown by the cytokine activity testing (IFN-γ, IL-6), the attenuated reassortant virus activates both Th1- and Th2-lymphocytes in NALT.This data suggest that intranasal immunization with live attenuated reassortant viruses (genetic formula 2/6) results into active and balanced stimulation of both Th1-and Th2-immune responses at the primary site of infection (NALT).G. D. PetukhovaA. N. NaikhinI. B. BarantsevaS. A. DoninaT. V. ChirkovaE. P. GrigorievaL. G. RudenkoSPb RAACIarticlelocal immune responsesinfluenza infectionvaccinationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 4, Pp 511-516 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	local immune responses influenza infection vaccination Immunologic diseases. Allergy RC581-607
spellingShingle	local immune responses influenza infection vaccination Immunologic diseases. Allergy RC581-607 G. D. Petukhova A. N. Naikhin I. B. Barantseva S. A. Donina T. V. Chirkova E. P. Grigorieva L. G. Rudenko LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
description	Abstract. Local immune responses of mucous membranes of an organism are the first and most significant barriers preventing many virus infections, including influenza. The barrier against influenza infection is the mucosalassociated lymphoid tissue of the upper airways. It is considered, that nasopharyngeal-associated lymphoid tissue (NALT) in rodents is an equivalent of lymphoid tissue in human Waldeyer’s ring. Present work is the first attempt to analyze and compare the development of cellular and antibody immune responses in NALT in a mouse model of experimental influenza infection using a pathogenic influenza A (H1N1) virus and an attenuated reassorted (2/6 genetic formula) live influenza A (H1N1) vaccine.It was shown, that the vaccine strain inherits the ability to induce high-grade local antibody responses like as the virulent parental strain. However, the vaccine strain is inferior to virulent parental strain in capacity to stimulate production of circulating antibodies. Both parental and Р 2/6 strains are equally able to induce lymphoproliferative immune response in NALT lymphocytes. The attenuated reassortant virus is able to stimulate proliferation of Th (CD4+), B-cells (CD19+) and CTL (CD8+) in NALT. As shown by the cytokine activity testing (IFN-γ, IL-6), the attenuated reassortant virus activates both Th1- and Th2-lymphocytes in NALT.This data suggest that intranasal immunization with live attenuated reassortant viruses (genetic formula 2/6) results into active and balanced stimulation of both Th1-and Th2-immune responses at the primary site of infection (NALT).
format	article
author	G. D. Petukhova A. N. Naikhin I. B. Barantseva S. A. Donina T. V. Chirkova E. P. Grigorieva L. G. Rudenko
author_facet	G. D. Petukhova A. N. Naikhin I. B. Barantseva S. A. Donina T. V. Chirkova E. P. Grigorieva L. G. Rudenko
author_sort	G. D. Petukhova
title	LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
title_short	LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
title_full	LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
title_fullStr	LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
title_full_unstemmed	LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION
title_sort	local antibody and cellular immune responses to influenza infection and vaccination
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/63deaaca60964ef5ae44a0c32db69f69
work_keys_str_mv	AT gdpetukhova localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT annaikhin localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT ibbarantseva localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT sadonina localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT tvchirkova localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT epgrigorieva localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination AT lgrudenko localantibodyandcellularimmuneresponsestoinfluenzainfectionandvaccination
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LOCAL ANTIBODY AND CELLULAR IMMUNE RESPONSES TO INFLUENZA INFECTION AND VACCINATION

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