The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice

Abstract The ribotoxin deoxynivalenol (DON) is a trichothecene found on cereals responsible for mycotoxicosis in both humans and farm animals. DON toxicity is characterized by reduced food intake, diminished nutritional efficiency and immunologic effects. The present study was designed to further ch...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rym Barbouche, Stéphanie Gaigé, Coraline Airault, Kevin Poirot, Michel Dallaporta, Jean-Denis Troadec, Anne Abysique
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63e179352a7d4c179b9a8e31b5180978
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63e179352a7d4c179b9a8e31b5180978
record_format	dspace
spelling	oai:doaj.org-article:63e179352a7d4c179b9a8e31b51809782021-12-02T17:55:13ZThe food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice10.1038/s41598-020-68712-w2045-2322https://doaj.org/article/63e179352a7d4c179b9a8e31b51809782020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68712-whttps://doaj.org/toc/2045-2322Abstract The ribotoxin deoxynivalenol (DON) is a trichothecene found on cereals responsible for mycotoxicosis in both humans and farm animals. DON toxicity is characterized by reduced food intake, diminished nutritional efficiency and immunologic effects. The present study was designed to further characterize the alterations in energy metabolism induced by DON intoxication. We demonstrated that acute DON intoxication triggered liver steatosis associated with an altered expression of genes related to lipids oxidation, lipogenesis and lipolysis. This steatosis was concomitant to anorexia, hypoglycemia and a paradoxical transient insulin release. DON treatment resulted also in stimulation of central autonomic network regulating sympathetic outflow and adrenaline and glucocorticoids secretion. Furthermore, an increased expression of genes linked to inflammation and reticulum endoplasmic stress was observed in the liver of DON-treated mice. Finally, we propose that lipids mobilization from adipose tissues (AT) induced by DON intoxication drives hepatic steatosis since (1) genes encoding lipolytic enzymes were up-regulated in AT and (2) plasma concentration of triglycerides (TGs) and non-esterified fatty acids were increased during DON intoxication. Altogether, these data demonstrate that DON induced hormonal and metabolic dysregulations associated with a spectrum of hepatic abnormalities, evocative of a non-alcoholic fatty liver disease.Rym BarboucheStéphanie GaigéCoraline AiraultKevin PoirotMichel DallaportaJean-Denis TroadecAnne AbysiqueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rym Barbouche Stéphanie Gaigé Coraline Airault Kevin Poirot Michel Dallaporta Jean-Denis Troadec Anne Abysique The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
description	Abstract The ribotoxin deoxynivalenol (DON) is a trichothecene found on cereals responsible for mycotoxicosis in both humans and farm animals. DON toxicity is characterized by reduced food intake, diminished nutritional efficiency and immunologic effects. The present study was designed to further characterize the alterations in energy metabolism induced by DON intoxication. We demonstrated that acute DON intoxication triggered liver steatosis associated with an altered expression of genes related to lipids oxidation, lipogenesis and lipolysis. This steatosis was concomitant to anorexia, hypoglycemia and a paradoxical transient insulin release. DON treatment resulted also in stimulation of central autonomic network regulating sympathetic outflow and adrenaline and glucocorticoids secretion. Furthermore, an increased expression of genes linked to inflammation and reticulum endoplasmic stress was observed in the liver of DON-treated mice. Finally, we propose that lipids mobilization from adipose tissues (AT) induced by DON intoxication drives hepatic steatosis since (1) genes encoding lipolytic enzymes were up-regulated in AT and (2) plasma concentration of triglycerides (TGs) and non-esterified fatty acids were increased during DON intoxication. Altogether, these data demonstrate that DON induced hormonal and metabolic dysregulations associated with a spectrum of hepatic abnormalities, evocative of a non-alcoholic fatty liver disease.
format	article
author	Rym Barbouche Stéphanie Gaigé Coraline Airault Kevin Poirot Michel Dallaporta Jean-Denis Troadec Anne Abysique
author_facet	Rym Barbouche Stéphanie Gaigé Coraline Airault Kevin Poirot Michel Dallaporta Jean-Denis Troadec Anne Abysique
author_sort	Rym Barbouche
title	The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
title_short	The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
title_full	The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
title_fullStr	The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
title_full_unstemmed	The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
title_sort	food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (nafl) in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63e179352a7d4c179b9a8e31b5180978
work_keys_str_mv	AT rymbarbouche thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT stephaniegaige thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT coralineairault thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT kevinpoirot thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT micheldallaporta thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT jeandenistroadec thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT anneabysique thefoodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT rymbarbouche foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT stephaniegaige foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT coralineairault foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT kevinpoirot foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT micheldallaporta foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT jeandenistroadec foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice AT anneabysique foodcontaminantdeoxynivalenolprovokesmetabolicimpairmentsresultinginnonalcoholicfattylivernaflinmice
_version_	1718379110035619840

The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice

Ejemplares similares