Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance

The limitations of hydrophilicity, strength, antibacterial activity adsorption performance of the biobased and biocompatible polymer materials, such as polyhydroxyalkanoates (PHAs), significantly restrict their wider applications especially in medical areas. In this paper, a novel composite membrane...

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Autores principales:	Yuandong Wu, Weishuang Zheng, Yinan Xiao, Beining Du, Xingru Zhang, Min Wen, Chen Lai, Yi Huang, Liyuan Sheng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MXene PHBV composite membrane hydrophilicity antibacterial properties coagulation Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/63e1aec1cdfb402488317702ac91aaf1
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spelling	oai:doaj.org-article:63e1aec1cdfb402488317702ac91aaf12021-11-11T18:46:15ZMultifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance10.3390/polym132137482073-4360https://doaj.org/article/63e1aec1cdfb402488317702ac91aaf12021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3748https://doaj.org/toc/2073-4360The limitations of hydrophilicity, strength, antibacterial activity adsorption performance of the biobased and biocompatible polymer materials, such as polyhydroxyalkanoates (PHAs), significantly restrict their wider applications especially in medical areas. In this paper, a novel composite membrane with high antibacterial activity and platelet adsorption performance was prepared based on graphene oxide (GO), MXene and 3-hydroxybutyrate-co-hydroxyvalerate (PHBV), which are medium-chain-length-copolymers of PHA. The GO/MXene nanosheets can uniformly inset on the surface of PHBV fibre and give the PHBV—GO/MXene composite membranes superior hydrophilicity due to the presence of hydroxyl groups and terminal oxygen on the surface of nanosheets, which further provides the functional site for the free radical polymerization of ester bonds between GO/MXene and PHBV. As a result, the tensile strength, platelet adsorption, and blood coagulation time of the PHBV—GO/MXene composite membranes were remarkably increased compared with those of the pure PHBV membranes. The antibacterial rate of the PHBV—GO/MXene composite membranes against gram-positive and gram-negative bacteria can reach 97% due to the antibacterial nature of MXene. The improved strength, hydrophilicity, antibacterial activity and platelet adsorption performance suggest that PHBV—GO/MXene composite membranes might be ideal candidates for multifunctional materials for haemostatic applications.Yuandong WuWeishuang ZhengYinan XiaoBeining DuXingru ZhangMin WenChen LaiYi HuangLiyuan ShengMDPI AGarticleMXenePHBVcomposite membranehydrophilicityantibacterial propertiescoagulationOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3748, p 3748 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MXene PHBV composite membrane hydrophilicity antibacterial properties coagulation Organic chemistry QD241-441
spellingShingle	MXene PHBV composite membrane hydrophilicity antibacterial properties coagulation Organic chemistry QD241-441 Yuandong Wu Weishuang Zheng Yinan Xiao Beining Du Xingru Zhang Min Wen Chen Lai Yi Huang Liyuan Sheng Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
description	The limitations of hydrophilicity, strength, antibacterial activity adsorption performance of the biobased and biocompatible polymer materials, such as polyhydroxyalkanoates (PHAs), significantly restrict their wider applications especially in medical areas. In this paper, a novel composite membrane with high antibacterial activity and platelet adsorption performance was prepared based on graphene oxide (GO), MXene and 3-hydroxybutyrate-co-hydroxyvalerate (PHBV), which are medium-chain-length-copolymers of PHA. The GO/MXene nanosheets can uniformly inset on the surface of PHBV fibre and give the PHBV—GO/MXene composite membranes superior hydrophilicity due to the presence of hydroxyl groups and terminal oxygen on the surface of nanosheets, which further provides the functional site for the free radical polymerization of ester bonds between GO/MXene and PHBV. As a result, the tensile strength, platelet adsorption, and blood coagulation time of the PHBV—GO/MXene composite membranes were remarkably increased compared with those of the pure PHBV membranes. The antibacterial rate of the PHBV—GO/MXene composite membranes against gram-positive and gram-negative bacteria can reach 97% due to the antibacterial nature of MXene. The improved strength, hydrophilicity, antibacterial activity and platelet adsorption performance suggest that PHBV—GO/MXene composite membranes might be ideal candidates for multifunctional materials for haemostatic applications.
format	article
author	Yuandong Wu Weishuang Zheng Yinan Xiao Beining Du Xingru Zhang Min Wen Chen Lai Yi Huang Liyuan Sheng
author_facet	Yuandong Wu Weishuang Zheng Yinan Xiao Beining Du Xingru Zhang Min Wen Chen Lai Yi Huang Liyuan Sheng
author_sort	Yuandong Wu
title	Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
title_short	Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
title_full	Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
title_fullStr	Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
title_full_unstemmed	Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance
title_sort	multifunctional, robust, and porous phbv—go/mxene composite membranes with good hydrophilicity, antibacterial activity, and platelet adsorption performance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63e1aec1cdfb402488317702ac91aaf1
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Multifunctional, Robust, and Porous PHBV—GO/MXene Composite Membranes with Good Hydrophilicity, Antibacterial Activity, and Platelet Adsorption Performance

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