The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes

Abstract Bark from the Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree has long been used in traditional South American healing practises to treat inflammation. However, its anti-inflammatory activity has not been closely examined. Here we use chemical extraction, qualitative ph...

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Autores principales:	Rachael Y. M. Ryan, Alejandra Fernandez, Yide Wong, John J. Miles, Ian E. Cock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63e32914da3f48598f0b3eb7d8a43b31
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spelling	oai:doaj.org-article:63e32914da3f48598f0b3eb7d8a43b312021-12-02T11:37:22ZThe medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes10.1038/s41598-021-85211-82045-2322https://doaj.org/article/63e32914da3f48598f0b3eb7d8a43b312021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85211-8https://doaj.org/toc/2045-2322Abstract Bark from the Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree has long been used in traditional South American healing practises to treat inflammation. However, its anti-inflammatory activity has not been closely examined. Here we use chemical extraction, qualitative phytochemical examination, toxicity testing and quantitative examination of anti-inflammatory activity on human cells ex vivo. All extracts were found to be nontoxic. We found different extracts exhibited unique cytokine profiles with some extracts outperforming a positive control used in the clinic. These results verify the immunomodulatory activity of Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree bark-derived compounds. Collectively, combining a lack of toxicity and potency in human immune cells supports further fractionation and research.Rachael Y. M. RyanAlejandra FernandezYide WongJohn J. MilesIan E. CockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rachael Y. M. Ryan Alejandra Fernandez Yide Wong John J. Miles Ian E. Cock The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
description	Abstract Bark from the Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree has long been used in traditional South American healing practises to treat inflammation. However, its anti-inflammatory activity has not been closely examined. Here we use chemical extraction, qualitative phytochemical examination, toxicity testing and quantitative examination of anti-inflammatory activity on human cells ex vivo. All extracts were found to be nontoxic. We found different extracts exhibited unique cytokine profiles with some extracts outperforming a positive control used in the clinic. These results verify the immunomodulatory activity of Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree bark-derived compounds. Collectively, combining a lack of toxicity and potency in human immune cells supports further fractionation and research.
format	article
author	Rachael Y. M. Ryan Alejandra Fernandez Yide Wong John J. Miles Ian E. Cock
author_facet	Rachael Y. M. Ryan Alejandra Fernandez Yide Wong John J. Miles Ian E. Cock
author_sort	Rachael Y. M. Ryan
title	The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
title_short	The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
title_full	The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
title_fullStr	The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
title_full_unstemmed	The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
title_sort	medicinal plant tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63e32914da3f48598f0b3eb7d8a43b31
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The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes

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