Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic Agents

The gene <i>TP53</i>, which encodes the tumor suppressor protein p53, is mutated in about 50% of cancers. In response to cell stressors like DNA damage and after treatment with DNA-damaging therapeutic agents, p53 acts as a transcription factor to activate subsets of target genes which c...

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Autores principales: Lindsey Carlsen, Wafik S. El-Deiry
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
p53
Acceso en línea:https://doaj.org/article/63e53515f0ec4079b1faa8341d961d21
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