The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. T...

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Autores principales:	Katarzyna Bialik-Wąs, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	wound dressings sodium alginate/poly(vinyl alcohol) matrices hydrogels glycerin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/63e5cc77b1eb4cc3ae0b9d14c225a3d0
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spelling	oai:doaj.org-article:63e5cc77b1eb4cc3ae0b9d14c225a3d02021-11-11T17:25:42ZThe Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application10.3390/ijms2221120221422-00671661-6596https://doaj.org/article/63e5cc77b1eb4cc3ae0b9d14c225a3d02021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12022https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. The study shows a significant decrease in the gel fraction from 80.5 ± 2.1% to 45.0 ± 1.2% with the increase of glycerin content. The T<sub>5</sub> values of the tested hydrogels were varied and range from 88.7 °C to 161.5 °C. The presence of glycerin in the matrices significantly decreased the thermal resistance, which was especially visible by T<sub>10</sub> changes (273.9 to 163.5 °C). The degradation tests indicate that most of the tested materials do not degrade throughout the incubation period and maintain a constant ion level after 7-day incubation. The swelling abilities in distilled water and phosphate buffer solution are approximately 200–300%. However, we noticed that these values decrease with the increase in glycerin content. All tested matrices are characterized by the maximum elongation rate at break in a range of 37.6–69.5%. The FT-IR analysis exhibits glycerin changes in hydrogel structures, which is associated with the cross-linking reaction. Additionally, cytotoxicity results indicate good adhesion properties and no toxicity towards normal human dermal fibroblasts.Katarzyna Bialik-WąsKlaudia PlutaDagmara MalinaMateusz BarczewskiKatarzyna MalarzAnna Mrozek-WilczkiewiczMDPI AGarticlewound dressingssodium alginate/poly(vinyl alcohol) matriceshydrogelsglycerinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12022, p 12022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound dressings sodium alginate/poly(vinyl alcohol) matrices hydrogels glycerin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	wound dressings sodium alginate/poly(vinyl alcohol) matrices hydrogels glycerin Biology (General) QH301-705.5 Chemistry QD1-999 Katarzyna Bialik-Wąs Klaudia Pluta Dagmara Malina Mateusz Barczewski Katarzyna Malarz Anna Mrozek-Wilczkiewicz The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
description	The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. The study shows a significant decrease in the gel fraction from 80.5 ± 2.1% to 45.0 ± 1.2% with the increase of glycerin content. The T<sub>5</sub> values of the tested hydrogels were varied and range from 88.7 °C to 161.5 °C. The presence of glycerin in the matrices significantly decreased the thermal resistance, which was especially visible by T<sub>10</sub> changes (273.9 to 163.5 °C). The degradation tests indicate that most of the tested materials do not degrade throughout the incubation period and maintain a constant ion level after 7-day incubation. The swelling abilities in distilled water and phosphate buffer solution are approximately 200–300%. However, we noticed that these values decrease with the increase in glycerin content. All tested matrices are characterized by the maximum elongation rate at break in a range of 37.6–69.5%. The FT-IR analysis exhibits glycerin changes in hydrogel structures, which is associated with the cross-linking reaction. Additionally, cytotoxicity results indicate good adhesion properties and no toxicity towards normal human dermal fibroblasts.
format	article
author	Katarzyna Bialik-Wąs Klaudia Pluta Dagmara Malina Mateusz Barczewski Katarzyna Malarz Anna Mrozek-Wilczkiewicz
author_facet	Katarzyna Bialik-Wąs Klaudia Pluta Dagmara Malina Mateusz Barczewski Katarzyna Malarz Anna Mrozek-Wilczkiewicz
author_sort	Katarzyna Bialik-Wąs
title	The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
title_short	The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
title_full	The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
title_fullStr	The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
title_full_unstemmed	The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application
title_sort	effect of glycerin content in sodium alginate/poly(vinyl alcohol)-based hydrogels for wound dressing application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63e5cc77b1eb4cc3ae0b9d14c225a3d0
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The Effect of Glycerin Content in Sodium Alginate/Poly(vinyl alcohol)-Based Hydrogels for Wound Dressing Application

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