Intestinal bacteria condition dendritic cells to promote IgA production.

Immunoglobulin (Ig) A represents the predominant antibody isotype produced at the intestinal mucosa, where it plays an important role in limiting the penetration of commensal intestinal bacteria and opportunistic pathogens. We show in mice that Peyer's Patch-derived dendritic cells (PP-DC) exhi...

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Autores principales:	Joanna C Massacand, Patrick Kaiser, Bettina Ernst, Aubry Tardivel, Kurt Bürki, Pascal Schneider, Nicola L Harris
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63ebd4ed1c064e71a2954042add02979
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spelling	oai:doaj.org-article:63ebd4ed1c064e71a2954042add029792021-11-25T06:11:48ZIntestinal bacteria condition dendritic cells to promote IgA production.1932-620310.1371/journal.pone.0002588https://doaj.org/article/63ebd4ed1c064e71a2954042add029792008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18596964/?tool=EBIhttps://doaj.org/toc/1932-6203Immunoglobulin (Ig) A represents the predominant antibody isotype produced at the intestinal mucosa, where it plays an important role in limiting the penetration of commensal intestinal bacteria and opportunistic pathogens. We show in mice that Peyer's Patch-derived dendritic cells (PP-DC) exhibit a specialized phenotype allowing the promotion of IgA production by B2 cells. This phenotype included increased expression of the retinaldehyde dehydrogenase 1 (RALDH1), inducible nitric oxide synthase (iNOS), B cell activating factor of the tumor necrosis family (BAFF), a proliferation-inducing ligand (APRIL), and receptors for the neuropeptide vasoactive intestinal peptide (VIP). The ability of PP-DC to promote anti-CD40 dependent IgA was partially dependent on retinoic acid (RA) and transforming growth factor (TGF)-beta, whilst BAFF and APRIL signaling were not required. Signals delivered by BAFF and APRIL were crucial for CD40 independent IgA production, although the contribution of B2 cells to this pathway was minimal. The unique ability of PP-DC to instruct naïve B cells to differentiate into IgA producing plasma cells was mainly imparted by the presence of intestinal commensal bacteria, and could be mimicked by the addition of LPS to the culture. These data indicate that exposure to pathogen-associated molecular patterns present on intestinal commensal bacteria condition DC to express a unique molecular footprint that in turn allows them to promote IgA production.Joanna C MassacandPatrick KaiserBettina ErnstAubry TardivelKurt BürkiPascal SchneiderNicola L HarrisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2588 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna C Massacand Patrick Kaiser Bettina Ernst Aubry Tardivel Kurt Bürki Pascal Schneider Nicola L Harris Intestinal bacteria condition dendritic cells to promote IgA production.
description	Immunoglobulin (Ig) A represents the predominant antibody isotype produced at the intestinal mucosa, where it plays an important role in limiting the penetration of commensal intestinal bacteria and opportunistic pathogens. We show in mice that Peyer's Patch-derived dendritic cells (PP-DC) exhibit a specialized phenotype allowing the promotion of IgA production by B2 cells. This phenotype included increased expression of the retinaldehyde dehydrogenase 1 (RALDH1), inducible nitric oxide synthase (iNOS), B cell activating factor of the tumor necrosis family (BAFF), a proliferation-inducing ligand (APRIL), and receptors for the neuropeptide vasoactive intestinal peptide (VIP). The ability of PP-DC to promote anti-CD40 dependent IgA was partially dependent on retinoic acid (RA) and transforming growth factor (TGF)-beta, whilst BAFF and APRIL signaling were not required. Signals delivered by BAFF and APRIL were crucial for CD40 independent IgA production, although the contribution of B2 cells to this pathway was minimal. The unique ability of PP-DC to instruct naïve B cells to differentiate into IgA producing plasma cells was mainly imparted by the presence of intestinal commensal bacteria, and could be mimicked by the addition of LPS to the culture. These data indicate that exposure to pathogen-associated molecular patterns present on intestinal commensal bacteria condition DC to express a unique molecular footprint that in turn allows them to promote IgA production.
format	article
author	Joanna C Massacand Patrick Kaiser Bettina Ernst Aubry Tardivel Kurt Bürki Pascal Schneider Nicola L Harris
author_facet	Joanna C Massacand Patrick Kaiser Bettina Ernst Aubry Tardivel Kurt Bürki Pascal Schneider Nicola L Harris
author_sort	Joanna C Massacand
title	Intestinal bacteria condition dendritic cells to promote IgA production.
title_short	Intestinal bacteria condition dendritic cells to promote IgA production.
title_full	Intestinal bacteria condition dendritic cells to promote IgA production.
title_fullStr	Intestinal bacteria condition dendritic cells to promote IgA production.
title_full_unstemmed	Intestinal bacteria condition dendritic cells to promote IgA production.
title_sort	intestinal bacteria condition dendritic cells to promote iga production.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/63ebd4ed1c064e71a2954042add02979
work_keys_str_mv	AT joannacmassacand intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT patrickkaiser intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT bettinaernst intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT aubrytardivel intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT kurtburki intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT pascalschneider intestinalbacteriaconditiondendriticcellstopromoteigaproduction AT nicolalharris intestinalbacteriaconditiondendriticcellstopromoteigaproduction
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Intestinal bacteria condition dendritic cells to promote IgA production.

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