Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Abstract Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard imaging techniques. Recent studies...

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Autores principales:	Mor Mishkovsky, Olga Gusyatiner, Bernard Lanz, Cristina Cudalbu, Irene Vassallo, Marie-France Hamou, Jocelyne Bloch, Arnaud Comment, Rolf Gruetter, Monika E. Hegi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63f02f86298445728f1acfcb8546e62d
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spelling	oai:doaj.org-article:63f02f86298445728f1acfcb8546e62d2021-12-02T11:37:19ZHyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma10.1038/s41598-021-85339-72045-2322https://doaj.org/article/63f02f86298445728f1acfcb8546e62d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85339-7https://doaj.org/toc/2045-2322Abstract Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard imaging techniques. Recent studies demonstrated distinct metabolic profiles of the invasive phenotype in GBM. Magnetic resonance (MR) of hyperpolarized 13C-labeled probes is a rapidly advancing field that provides real-time metabolic information. Here, we applied hyperpolarized 13C-glucose MR to mouse GBM models. Compared to controls, the amount of lactate produced from hyperpolarized glucose was higher in the compact GBM model, consistent with the accepted “Warburg effect”. However, the opposite response was observed in models reflecting the invasive zone, with less lactate produced than in controls, implying a reduction in aerobic glycolysis. These striking differences could be used to map the metabolic heterogeneity in GBM and to visualize the infiltrative front of GBM.Mor MishkovskyOlga GusyatinerBernard LanzCristina CudalbuIrene VassalloMarie-France HamouJocelyne BlochArnaud CommentRolf GruetterMonika E. HegiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mor Mishkovsky Olga Gusyatiner Bernard Lanz Cristina Cudalbu Irene Vassallo Marie-France Hamou Jocelyne Bloch Arnaud Comment Rolf Gruetter Monika E. Hegi Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
description	Abstract Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard imaging techniques. Recent studies demonstrated distinct metabolic profiles of the invasive phenotype in GBM. Magnetic resonance (MR) of hyperpolarized 13C-labeled probes is a rapidly advancing field that provides real-time metabolic information. Here, we applied hyperpolarized 13C-glucose MR to mouse GBM models. Compared to controls, the amount of lactate produced from hyperpolarized glucose was higher in the compact GBM model, consistent with the accepted “Warburg effect”. However, the opposite response was observed in models reflecting the invasive zone, with less lactate produced than in controls, implying a reduction in aerobic glycolysis. These striking differences could be used to map the metabolic heterogeneity in GBM and to visualize the infiltrative front of GBM.
format	article
author	Mor Mishkovsky Olga Gusyatiner Bernard Lanz Cristina Cudalbu Irene Vassallo Marie-France Hamou Jocelyne Bloch Arnaud Comment Rolf Gruetter Monika E. Hegi
author_facet	Mor Mishkovsky Olga Gusyatiner Bernard Lanz Cristina Cudalbu Irene Vassallo Marie-France Hamou Jocelyne Bloch Arnaud Comment Rolf Gruetter Monika E. Hegi
author_sort	Mor Mishkovsky
title	Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
title_short	Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
title_full	Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
title_fullStr	Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
title_full_unstemmed	Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
title_sort	hyperpolarized 13c-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63f02f86298445728f1acfcb8546e62d
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Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

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