The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know

ABSTRACT Autism spectrum disorder (ASD) is a remarkably complex disorder influenced by both genetic and environmental factors. Numerous microbial diversity surveys conducted over the past decade have attempted to link specific ASD biomarkers to gastrointestinal tract disturbances, but results genera...

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Autor principal:	Maude M. David
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	autism spectrum disorder microbiota Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/63f465020d8e4d358f98cb2edcd5f153
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spelling	oai:doaj.org-article:63f465020d8e4d358f98cb2edcd5f1532021-12-02T19:36:39ZThe Role of the Microbiome in Autism: All That We Know about All That We Don’t Know10.1128/mSystems.00234-212379-5077https://doaj.org/article/63f465020d8e4d358f98cb2edcd5f1532021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00234-21https://doaj.org/toc/2379-5077ABSTRACT Autism spectrum disorder (ASD) is a remarkably complex disorder influenced by both genetic and environmental factors. Numerous microbial diversity surveys conducted over the past decade have attempted to link specific ASD biomarkers to gastrointestinal tract disturbances, but results generated across cohorts and studies remain inconsistent. This commentary discusses multidirectional interactions between the host, the microbiome, and external factors germane to autism. Recent studies posit the heritability of the gut microbiome itself, confounding attempts to discern heritable from nonheritable effectors in neurodevelopmental disorders. Elucidating the ever-evolving gut microbiome’s role in modulating the ASD phenotype will most certainly require new experimental methodologies and designs. In a recent paper published in mSystems (J. Fouquier, N. Moreno Huizar, J. Donnelly, C. Glickman, et al., mSystems e00848-20, 2021, https://doi.org/10.1128/mSystems.00848-20), the authors describe a web of interactions by collecting samples longitudinally, analyzing cross-sectional cohorts, and recording nonbinary phenotypic measurements.Maude M. DavidAmerican Society for Microbiologyarticleautism spectrum disordermicrobiotaMicrobiologyQR1-502ENmSystems, Vol 6, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder microbiota Microbiology QR1-502
spellingShingle	autism spectrum disorder microbiota Microbiology QR1-502 Maude M. David The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
description	ABSTRACT Autism spectrum disorder (ASD) is a remarkably complex disorder influenced by both genetic and environmental factors. Numerous microbial diversity surveys conducted over the past decade have attempted to link specific ASD biomarkers to gastrointestinal tract disturbances, but results generated across cohorts and studies remain inconsistent. This commentary discusses multidirectional interactions between the host, the microbiome, and external factors germane to autism. Recent studies posit the heritability of the gut microbiome itself, confounding attempts to discern heritable from nonheritable effectors in neurodevelopmental disorders. Elucidating the ever-evolving gut microbiome’s role in modulating the ASD phenotype will most certainly require new experimental methodologies and designs. In a recent paper published in mSystems (J. Fouquier, N. Moreno Huizar, J. Donnelly, C. Glickman, et al., mSystems e00848-20, 2021, https://doi.org/10.1128/mSystems.00848-20), the authors describe a web of interactions by collecting samples longitudinally, analyzing cross-sectional cohorts, and recording nonbinary phenotypic measurements.
format	article
author	Maude M. David
author_facet	Maude M. David
author_sort	Maude M. David
title	The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
title_short	The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
title_full	The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
title_fullStr	The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
title_full_unstemmed	The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know
title_sort	role of the microbiome in autism: all that we know about all that we don’t know
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/63f465020d8e4d358f98cb2edcd5f153
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The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know

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