The features of reproductive health in women with multiple sclerosis

Introduction. The incidence of multiple sclerosis (MS) is two times higher in women, and the debut of the disease falls on young reproductive age, which makes the problem urgent. Purpose: to assess the characteristics of the reproductive health of women with MS in different age periods. Material and...

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Autores principales:	O. A. Tikhonovskaya, A. Yu. Kochetkova, V. M. Alifirova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	multiple sclerosis pregnancy reproductive health sex steroids Science Q
Acceso en línea:	https://doaj.org/article/63f4f0d37b8d4a1c8bb53469b52fe62a
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spelling	oai:doaj.org-article:63f4f0d37b8d4a1c8bb53469b52fe62a2021-11-23T06:14:38ZThe features of reproductive health in women with multiple sclerosis2541-94202587-959610.12737/article_59e85954b59223.59077292https://doaj.org/article/63f4f0d37b8d4a1c8bb53469b52fe62a2017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/428https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Introduction. The incidence of multiple sclerosis (MS) is two times higher in women, and the debut of the disease falls on young reproductive age, which makes the problem urgent. Purpose: to assess the characteristics of the reproductive health of women with MS in different age periods. Material and methods. A prospective study was carried out in parallel groups and a case-control study of women of early and late reproductive age with a reliable diagnosis of MS. Results. During pregnancy, there was a significant decrease in the frequency of exacerbations of MS in comparison with the pre-gravity period; voluntary infertility and childlessness is registered in 21.3 % and 32 % of women, respectively. An increase in the concentration of follicle stimulating hormone (FSH) means an increase in the degree of disability on the Expanded Disability Status Scale (EDSS) and the duration of the disease. The decrease in the concentration of dehydroepiandrosterone sulfate (DHEA-S) corresponds to a higher degree of disability on the EDSS scale and the duration of the disease. Conclusion. Pregnancy has a protective effect on the clinical course of MS. Infertility in most cases is voluntary, but at the same time hypergonadotropic condition and hypoandrogenia are observed in women with MS already in the early reproductive age, which interferes with the steroid synthetic function of the ovaries and can cause impaired fertility.O. A. TikhonovskayaA. Yu. KochetkovaV. M. AlifirovaScientific Сentre for Family Health and Human Reproduction Problemsarticlemultiple sclerosispregnancyreproductive healthsex steroidsScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 26-31 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	multiple sclerosis pregnancy reproductive health sex steroids Science Q
spellingShingle	multiple sclerosis pregnancy reproductive health sex steroids Science Q O. A. Tikhonovskaya A. Yu. Kochetkova V. M. Alifirova The features of reproductive health in women with multiple sclerosis
description	Introduction. The incidence of multiple sclerosis (MS) is two times higher in women, and the debut of the disease falls on young reproductive age, which makes the problem urgent. Purpose: to assess the characteristics of the reproductive health of women with MS in different age periods. Material and methods. A prospective study was carried out in parallel groups and a case-control study of women of early and late reproductive age with a reliable diagnosis of MS. Results. During pregnancy, there was a significant decrease in the frequency of exacerbations of MS in comparison with the pre-gravity period; voluntary infertility and childlessness is registered in 21.3 % and 32 % of women, respectively. An increase in the concentration of follicle stimulating hormone (FSH) means an increase in the degree of disability on the Expanded Disability Status Scale (EDSS) and the duration of the disease. The decrease in the concentration of dehydroepiandrosterone sulfate (DHEA-S) corresponds to a higher degree of disability on the EDSS scale and the duration of the disease. Conclusion. Pregnancy has a protective effect on the clinical course of MS. Infertility in most cases is voluntary, but at the same time hypergonadotropic condition and hypoandrogenia are observed in women with MS already in the early reproductive age, which interferes with the steroid synthetic function of the ovaries and can cause impaired fertility.
format	article
author	O. A. Tikhonovskaya A. Yu. Kochetkova V. M. Alifirova
author_facet	O. A. Tikhonovskaya A. Yu. Kochetkova V. M. Alifirova
author_sort	O. A. Tikhonovskaya
title	The features of reproductive health in women with multiple sclerosis
title_short	The features of reproductive health in women with multiple sclerosis
title_full	The features of reproductive health in women with multiple sclerosis
title_fullStr	The features of reproductive health in women with multiple sclerosis
title_full_unstemmed	The features of reproductive health in women with multiple sclerosis
title_sort	features of reproductive health in women with multiple sclerosis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/63f4f0d37b8d4a1c8bb53469b52fe62a
work_keys_str_mv	AT oatikhonovskaya thefeaturesofreproductivehealthinwomenwithmultiplesclerosis AT ayukochetkova thefeaturesofreproductivehealthinwomenwithmultiplesclerosis AT vmalifirova thefeaturesofreproductivehealthinwomenwithmultiplesclerosis AT oatikhonovskaya featuresofreproductivehealthinwomenwithmultiplesclerosis AT ayukochetkova featuresofreproductivehealthinwomenwithmultiplesclerosis AT vmalifirova featuresofreproductivehealthinwomenwithmultiplesclerosis
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The features of reproductive health in women with multiple sclerosis

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