Advanced glycation end products as predictors of renal function in youth with type 1 diabetes

Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/...

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Autores principales:	Josephine M. Forbes, Selena Le Bagge, Samuel Righi, Amelia K. Fotheringham, Linda A. Gallo, Domenica A. McCarthy, Sherman Leung, Tracey Baskerville, Janelle Nisbett, Adam Morton, Stephanie Teasdale, Neisha D’Silva, Helen Barrett, Timothy Jones, Jennifer Couper, Kim Donaghue, Nicole Isbel, David W. Johnson, Leigh Donnellan, Permal Deo, Lisa K. Akison, Karen M. Moritz, Trisha O’Moore-Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63f9c5c97c1c4806aeb2dec23ed2a3a1
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spelling	oai:doaj.org-article:63f9c5c97c1c4806aeb2dec23ed2a3a12021-12-02T14:49:33ZAdvanced glycation end products as predictors of renal function in youth with type 1 diabetes10.1038/s41598-021-88786-42045-2322https://doaj.org/article/63f9c5c97c1c4806aeb2dec23ed2a3a12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88786-4https://doaj.org/toc/2045-2322Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model < 2.2 × 10–16) and random blood glucose concentrations (56%; P model < 2.2 × 10–16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes.Josephine M. ForbesSelena Le BaggeSamuel RighiAmelia K. FotheringhamLinda A. GalloDomenica A. McCarthySherman LeungTracey BaskervilleJanelle NisbettAdam MortonStephanie TeasdaleNeisha D’SilvaHelen BarrettTimothy JonesJennifer CouperKim DonaghueNicole IsbelDavid W. JohnsonLeigh DonnellanPermal DeoLisa K. AkisonKaren M. MoritzTrisha O’Moore-SullivanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
description	Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model < 2.2 × 10–16) and random blood glucose concentrations (56%; P model < 2.2 × 10–16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes.
format	article
author	Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan
author_facet	Josephine M. Forbes Selena Le Bagge Samuel Righi Amelia K. Fotheringham Linda A. Gallo Domenica A. McCarthy Sherman Leung Tracey Baskerville Janelle Nisbett Adam Morton Stephanie Teasdale Neisha D’Silva Helen Barrett Timothy Jones Jennifer Couper Kim Donaghue Nicole Isbel David W. Johnson Leigh Donnellan Permal Deo Lisa K. Akison Karen M. Moritz Trisha O’Moore-Sullivan
author_sort	Josephine M. Forbes
title	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
title_short	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
title_full	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
title_fullStr	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
title_full_unstemmed	Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
title_sort	advanced glycation end products as predictors of renal function in youth with type 1 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63f9c5c97c1c4806aeb2dec23ed2a3a1
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Advanced glycation end products as predictors of renal function in youth with type 1 diabetes

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