Induced Neurons From Germ Cells in Caenorhabditis elegans

Cell fate conversion by the forced overexpression of transcription factors (TFs) is a process known as reprogramming. It leads to de-differentiation or trans-differentiation of mature cells, which could then be used for regenerative medicine applications to replenish patients suffering from, e.g., n...

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Autores principales:	Iris Marchal, Baris Tursun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	germline neuron reprogramming epigenetics chromatin safeguarding Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/63f9c65582054e7f8bd353e319d3ec6e
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spelling	oai:doaj.org-article:63f9c65582054e7f8bd353e319d3ec6e2021-12-03T05:33:02ZInduced Neurons From Germ Cells in Caenorhabditis elegans1662-453X10.3389/fnins.2021.771687https://doaj.org/article/63f9c65582054e7f8bd353e319d3ec6e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.771687/fullhttps://doaj.org/toc/1662-453XCell fate conversion by the forced overexpression of transcription factors (TFs) is a process known as reprogramming. It leads to de-differentiation or trans-differentiation of mature cells, which could then be used for regenerative medicine applications to replenish patients suffering from, e.g., neurodegenerative diseases, with healthy neurons. However, TF-induced reprogramming is often restricted due to cell fate safeguarding mechanisms, which require a better understanding to increase reprogramming efficiency and achieve higher fidelity. The germline of the nematode Caenorhabditis elegans has been a powerful model to investigate the impediments of generating neurons from germ cells by reprogramming. A number of conserved factors have been identified that act as a barrier for TF-induced direct reprogramming of germ cells to neurons. In this review, we will first summarize our current knowledge regarding cell fate safeguarding mechanisms in the germline. Then, we will focus on the molecular mechanisms underlying neuronal induction from germ cells upon TF-mediated reprogramming. We will shortly discuss the specific characteristics that might make germ cells especially fit to change cellular fate and become neurons. For future perspectives, we will look at the potential of C. elegans research in advancing our knowledge of the mechanisms that regulate cellular identity, and what implications this has for therapeutic approaches such as regenerative medicine.Iris MarchalIris MarchalBaris TursunBaris TursunBaris TursunFrontiers Media S.A.articlegermlineneuronreprogrammingepigeneticschromatinsafeguardingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	germline neuron reprogramming epigenetics chromatin safeguarding Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	germline neuron reprogramming epigenetics chromatin safeguarding Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Iris Marchal Iris Marchal Baris Tursun Baris Tursun Baris Tursun Induced Neurons From Germ Cells in Caenorhabditis elegans
description	Cell fate conversion by the forced overexpression of transcription factors (TFs) is a process known as reprogramming. It leads to de-differentiation or trans-differentiation of mature cells, which could then be used for regenerative medicine applications to replenish patients suffering from, e.g., neurodegenerative diseases, with healthy neurons. However, TF-induced reprogramming is often restricted due to cell fate safeguarding mechanisms, which require a better understanding to increase reprogramming efficiency and achieve higher fidelity. The germline of the nematode Caenorhabditis elegans has been a powerful model to investigate the impediments of generating neurons from germ cells by reprogramming. A number of conserved factors have been identified that act as a barrier for TF-induced direct reprogramming of germ cells to neurons. In this review, we will first summarize our current knowledge regarding cell fate safeguarding mechanisms in the germline. Then, we will focus on the molecular mechanisms underlying neuronal induction from germ cells upon TF-mediated reprogramming. We will shortly discuss the specific characteristics that might make germ cells especially fit to change cellular fate and become neurons. For future perspectives, we will look at the potential of C. elegans research in advancing our knowledge of the mechanisms that regulate cellular identity, and what implications this has for therapeutic approaches such as regenerative medicine.
format	article
author	Iris Marchal Iris Marchal Baris Tursun Baris Tursun Baris Tursun
author_facet	Iris Marchal Iris Marchal Baris Tursun Baris Tursun Baris Tursun
author_sort	Iris Marchal
title	Induced Neurons From Germ Cells in Caenorhabditis elegans
title_short	Induced Neurons From Germ Cells in Caenorhabditis elegans
title_full	Induced Neurons From Germ Cells in Caenorhabditis elegans
title_fullStr	Induced Neurons From Germ Cells in Caenorhabditis elegans
title_full_unstemmed	Induced Neurons From Germ Cells in Caenorhabditis elegans
title_sort	induced neurons from germ cells in caenorhabditis elegans
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/63f9c65582054e7f8bd353e319d3ec6e
work_keys_str_mv	AT irismarchal inducedneuronsfromgermcellsincaenorhabditiselegans AT irismarchal inducedneuronsfromgermcellsincaenorhabditiselegans AT baristursun inducedneuronsfromgermcellsincaenorhabditiselegans AT baristursun inducedneuronsfromgermcellsincaenorhabditiselegans AT baristursun inducedneuronsfromgermcellsincaenorhabditiselegans
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Induced Neurons From Germ Cells in Caenorhabditis elegans

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