Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages

Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the ba...

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Autores principales:	Deyanira Pérez-Morales, Víctor H. Bustamante
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63fab76c789d451a8939336b692d4b8e
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spelling	oai:doaj.org-article:63fab76c789d451a8939336b692d4b8e2021-12-02T16:35:53ZCross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages10.1038/s41467-021-22198-w2041-1723https://doaj.org/article/63fab76c789d451a8939336b692d4b8e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22198-whttps://doaj.org/toc/2041-1723Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.Deyanira Pérez-MoralesVíctor H. BustamanteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deyanira Pérez-Morales Víctor H. Bustamante Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
description	Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.
format	article
author	Deyanira Pérez-Morales Víctor H. Bustamante
author_facet	Deyanira Pérez-Morales Víctor H. Bustamante
author_sort	Deyanira Pérez-Morales
title	Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_short	Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_full	Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_fullStr	Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_full_unstemmed	Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
title_sort	cross-kingdom metabolic manipulation promotes salmonella replication inside macrophages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63fab76c789d451a8939336b692d4b8e
work_keys_str_mv	AT deyaniraperezmorales crosskingdommetabolicmanipulationpromotessalmonellareplicationinsidemacrophages AT victorhbustamante crosskingdommetabolicmanipulationpromotessalmonellareplicationinsidemacrophages
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Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages

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