Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition

Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process leads to the increase of free radicals and the so-called reactive ox...

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Autores principales:	Nancy Vargas-Mendoza, Marcelo Angeles-Valencia, Ángel Morales-González, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, José Gutiérrez-Salinas, César Esquivel-Chirino, Germán Chamorro-Cevallos, José Melesio Cristóbal-Luna, José A. Morales-González
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress ROS/RNS exercise mitochondrial adaptation oxidative damage antioxidants Science Q
Acceso en línea:	https://doaj.org/article/63fbe34cb4f54261b88d6e80c3142d80
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spelling	oai:doaj.org-article:63fbe34cb4f54261b88d6e80c3142d802021-11-25T18:11:46ZOxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition10.3390/life111112692075-1729https://doaj.org/article/63fbe34cb4f54261b88d6e80c3142d802021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1269https://doaj.org/toc/2075-1729Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process leads to the increase of free radicals and the so-called reactive oxygen species (ROS), which are necessary for the maintenance of cell signaling and homeostasis. In addition, mitochondrial biogenesis is influenced by exercise in continuous crosstalk between the mitochondria and the nuclear genome. Excessive workloads may induce severe mitochondrial stress, resulting in oxidative damage. In this regard, the objective of this work was to provide a general overview of the molecular mechanisms involved in mitochondrial adaptation during exercise and to understand if some nutrients such as antioxidants may be implicated in blunt adaptation and/or an impact on the performance of exercise by different means.Nancy Vargas-MendozaMarcelo Angeles-ValenciaÁngel Morales-GonzálezEduardo Osiris Madrigal-SantillánMauricio Morales-MartínezEduardo Madrigal-BujaidarIsela Álvarez-GonzálezJosé Gutiérrez-SalinasCésar Esquivel-ChirinoGermán Chamorro-CevallosJosé Melesio Cristóbal-LunaJosé A. Morales-GonzálezMDPI AGarticleoxidative stressROS/RNSexercisemitochondrial adaptationoxidative damageantioxidantsScienceQENLife, Vol 11, Iss 1269, p 1269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress ROS/RNS exercise mitochondrial adaptation oxidative damage antioxidants Science Q
spellingShingle	oxidative stress ROS/RNS exercise mitochondrial adaptation oxidative damage antioxidants Science Q Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Eduardo Osiris Madrigal-Santillán Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González José Gutiérrez-Salinas César Esquivel-Chirino Germán Chamorro-Cevallos José Melesio Cristóbal-Luna José A. Morales-González Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
description	Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process leads to the increase of free radicals and the so-called reactive oxygen species (ROS), which are necessary for the maintenance of cell signaling and homeostasis. In addition, mitochondrial biogenesis is influenced by exercise in continuous crosstalk between the mitochondria and the nuclear genome. Excessive workloads may induce severe mitochondrial stress, resulting in oxidative damage. In this regard, the objective of this work was to provide a general overview of the molecular mechanisms involved in mitochondrial adaptation during exercise and to understand if some nutrients such as antioxidants may be implicated in blunt adaptation and/or an impact on the performance of exercise by different means.
format	article
author	Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Eduardo Osiris Madrigal-Santillán Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González José Gutiérrez-Salinas César Esquivel-Chirino Germán Chamorro-Cevallos José Melesio Cristóbal-Luna José A. Morales-González
author_facet	Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Eduardo Osiris Madrigal-Santillán Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González José Gutiérrez-Salinas César Esquivel-Chirino Germán Chamorro-Cevallos José Melesio Cristóbal-Luna José A. Morales-González
author_sort	Nancy Vargas-Mendoza
title	Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
title_short	Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
title_full	Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
title_fullStr	Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
title_full_unstemmed	Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition
title_sort	oxidative stress, mitochondrial function and adaptation to exercise: new perspectives in nutrition
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63fbe34cb4f54261b88d6e80c3142d80
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Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition

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