NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis

Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ra...

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Autores principales:	Xiaoping Zhao, Zhi Xu, Haoseng Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce8
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spelling	oai:doaj.org-article:63fc3922919a4027b8b11c86c0338ce82021-12-02T15:05:45ZNSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis10.1038/s41598-017-01644-02045-2322https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce82017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01644-0https://doaj.org/toc/2045-2322Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ratio (HR) with 95% confidence intervals (CIs) for the associations of interested outcomes were included. Pooled effect estimates were obtained by using random- or fixed-effect model depending on the heterogeneity across these studies. Sixteen studies involving 202780 participants, including prostate, breast, lung, and colorectal cancer patients, were included. Compared with the reference, generally patients exposed to NSAIDs at pre- and post-diagnosis experienced a significantly reduced risk of distant metastasis (RR 0.708, 95% CI 0.586–0.856 and RR: 0.484, 95% CI: 0.393–0.595, respectively), including prostate cancer (pre-diagnostic use: RR = 0.874, 95% CI, 0.787–0.97; post-diagnostic use: RR = 0.482, 95% CI 0.359–0.647), and breast cancer (pre-diagnostic use: RR = 0.644, 95% CI 0.565–0.735; post-diagnostic use: RR = 0.485, 95% CI 0.362–0.651). However, lymph node metastasis was weakly related with pre-diagnostic use of NSAIDs (RR = 0.949, 95% CI 0.914–0.985). NSAIDs are related to a significantly reduced risk of metastasis development, regardless of pre-diagnostic or post-diagnostic use. However, NSAIDs and lymph node metastasis are weakly associated. Our finding suggested a novel metastasis management.Xiaoping ZhaoZhi XuHaoseng LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoping Zhao Zhi Xu Haoseng Li NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
description	Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ratio (HR) with 95% confidence intervals (CIs) for the associations of interested outcomes were included. Pooled effect estimates were obtained by using random- or fixed-effect model depending on the heterogeneity across these studies. Sixteen studies involving 202780 participants, including prostate, breast, lung, and colorectal cancer patients, were included. Compared with the reference, generally patients exposed to NSAIDs at pre- and post-diagnosis experienced a significantly reduced risk of distant metastasis (RR 0.708, 95% CI 0.586–0.856 and RR: 0.484, 95% CI: 0.393–0.595, respectively), including prostate cancer (pre-diagnostic use: RR = 0.874, 95% CI, 0.787–0.97; post-diagnostic use: RR = 0.482, 95% CI 0.359–0.647), and breast cancer (pre-diagnostic use: RR = 0.644, 95% CI 0.565–0.735; post-diagnostic use: RR = 0.485, 95% CI 0.362–0.651). However, lymph node metastasis was weakly related with pre-diagnostic use of NSAIDs (RR = 0.949, 95% CI 0.914–0.985). NSAIDs are related to a significantly reduced risk of metastasis development, regardless of pre-diagnostic or post-diagnostic use. However, NSAIDs and lymph node metastasis are weakly associated. Our finding suggested a novel metastasis management.
format	article
author	Xiaoping Zhao Zhi Xu Haoseng Li
author_facet	Xiaoping Zhao Zhi Xu Haoseng Li
author_sort	Xiaoping Zhao
title	NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_short	NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_full	NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_fullStr	NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_full_unstemmed	NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_sort	nsaids use and reduced metastasis in cancer patients: results from a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce8
work_keys_str_mv	AT xiaopingzhao nsaidsuseandreducedmetastasisincancerpatientsresultsfromametaanalysis AT zhixu nsaidsuseandreducedmetastasisincancerpatientsresultsfromametaanalysis AT haosengli nsaidsuseandreducedmetastasisincancerpatientsresultsfromametaanalysis
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NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis

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