NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis

Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ra...

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Autores principales: Xiaoping Zhao, Zhi Xu, Haoseng Li
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce8
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spelling oai:doaj.org-article:63fc3922919a4027b8b11c86c0338ce82021-12-02T15:05:45ZNSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis10.1038/s41598-017-01644-02045-2322https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce82017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01644-0https://doaj.org/toc/2045-2322Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ratio (HR) with 95% confidence intervals (CIs) for the associations of interested outcomes were included. Pooled effect estimates were obtained by using random- or fixed-effect model depending on the heterogeneity across these studies. Sixteen studies involving 202780 participants, including prostate, breast, lung, and colorectal cancer patients, were included. Compared with the reference, generally patients exposed to NSAIDs at pre- and post-diagnosis experienced a significantly reduced risk of distant metastasis (RR 0.708, 95% CI 0.586–0.856 and RR: 0.484, 95% CI: 0.393–0.595, respectively), including prostate cancer (pre-diagnostic use: RR = 0.874, 95% CI, 0.787–0.97; post-diagnostic use: RR = 0.482, 95% CI 0.359–0.647), and breast cancer (pre-diagnostic use: RR = 0.644, 95% CI 0.565–0.735; post-diagnostic use: RR = 0.485, 95% CI 0.362–0.651). However, lymph node metastasis was weakly related with pre-diagnostic use of NSAIDs (RR = 0.949, 95% CI 0.914–0.985). NSAIDs are related to a significantly reduced risk of metastasis development, regardless of pre-diagnostic or post-diagnostic use. However, NSAIDs and lymph node metastasis are weakly associated. Our finding suggested a novel metastasis management.Xiaoping ZhaoZhi XuHaoseng LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Xiaoping Zhao
Zhi Xu
Haoseng Li
NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
description Abstract This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, and Cochrane Library. Studies that reported the odds ratio (OR)/risk ratio (RR)/hazard ratio (HR) with 95% confidence intervals (CIs) for the associations of interested outcomes were included. Pooled effect estimates were obtained by using random- or fixed-effect model depending on the heterogeneity across these studies. Sixteen studies involving 202780 participants, including prostate, breast, lung, and colorectal cancer patients, were included. Compared with the reference, generally patients exposed to NSAIDs at pre- and post-diagnosis experienced a significantly reduced risk of distant metastasis (RR 0.708, 95% CI 0.586–0.856 and RR: 0.484, 95% CI: 0.393–0.595, respectively), including prostate cancer (pre-diagnostic use: RR = 0.874, 95% CI, 0.787–0.97; post-diagnostic use: RR = 0.482, 95% CI 0.359–0.647), and breast cancer (pre-diagnostic use: RR = 0.644, 95% CI 0.565–0.735; post-diagnostic use: RR = 0.485, 95% CI 0.362–0.651). However, lymph node metastasis was weakly related with pre-diagnostic use of NSAIDs (RR = 0.949, 95% CI 0.914–0.985). NSAIDs are related to a significantly reduced risk of metastasis development, regardless of pre-diagnostic or post-diagnostic use. However, NSAIDs and lymph node metastasis are weakly associated. Our finding suggested a novel metastasis management.
format article
author Xiaoping Zhao
Zhi Xu
Haoseng Li
author_facet Xiaoping Zhao
Zhi Xu
Haoseng Li
author_sort Xiaoping Zhao
title NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_short NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_full NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_fullStr NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_full_unstemmed NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
title_sort nsaids use and reduced metastasis in cancer patients: results from a meta-analysis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/63fc3922919a4027b8b11c86c0338ce8
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