B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells

Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, which has the second highest incidence among gastrointestinal tumors. At present, due to the limitations of current CRC treatment strategies, there is an urgent need for developing more effective therapies. B7 family membe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuzhen Yin, Lili Shi, Jing Yang, Hui Wang, Hang Yang, Qiang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	b7-h4 emt wnt signaling pathway colorectal cancer Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/63fc4503e31147c5ae053b6b687d2645
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63fc4503e31147c5ae053b6b687d2645
record_format	dspace
spelling	oai:doaj.org-article:63fc4503e31147c5ae053b6b687d26452021-11-26T11:19:50ZB7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells2165-59792165-598710.1080/21655979.2021.2009411https://doaj.org/article/63fc4503e31147c5ae053b6b687d26452021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2009411https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, which has the second highest incidence among gastrointestinal tumors. At present, due to the limitations of current CRC treatment strategies, there is an urgent need for developing more effective therapies. B7 family member H4 (B7-H4) is associated with the progression of a wide spectrum of cancers, but its functional role in CRC is unknown. The purpose of this study is to clarify the role of B7-H4 in CRC and the underlying mechanisms in controlling the progression of CRC. Our data showed that B7-H4 expression in CRC tissues and cell lines was significantly upregulated as compared with normal tissues and normal cell lines. High B7-H4 expression was correlated with a poor prognosis of CRC patients. B7-H4 overexpression promoted the proliferation and invasion of CRC cells, which could be suppressed by Wnt signaling inhibitor. In a mouse xenograft model, silencing B7-H4 suppressed tumor growth and epithelial-mesenchymal transition (EMT) of CRC cells. Collectively, our study demonstrated the oncogenic roles of B7-H4 in regulating the proliferation, EMT as well as the migration of CRC cells through Wnt signaling pathway. The heightened expression of B7-H4 could serve as a prognostic marker for CRC patients.Yuzhen YinLili ShiJing YangHui WangHang YangQiang WangTaylor & Francis Grouparticleb7-h4emtwnt signaling pathwaycolorectal cancerBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	b7-h4 emt wnt signaling pathway colorectal cancer Biotechnology TP248.13-248.65
spellingShingle	b7-h4 emt wnt signaling pathway colorectal cancer Biotechnology TP248.13-248.65 Yuzhen Yin Lili Shi Jing Yang Hui Wang Hang Yang Qiang Wang B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
description	Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, which has the second highest incidence among gastrointestinal tumors. At present, due to the limitations of current CRC treatment strategies, there is an urgent need for developing more effective therapies. B7 family member H4 (B7-H4) is associated with the progression of a wide spectrum of cancers, but its functional role in CRC is unknown. The purpose of this study is to clarify the role of B7-H4 in CRC and the underlying mechanisms in controlling the progression of CRC. Our data showed that B7-H4 expression in CRC tissues and cell lines was significantly upregulated as compared with normal tissues and normal cell lines. High B7-H4 expression was correlated with a poor prognosis of CRC patients. B7-H4 overexpression promoted the proliferation and invasion of CRC cells, which could be suppressed by Wnt signaling inhibitor. In a mouse xenograft model, silencing B7-H4 suppressed tumor growth and epithelial-mesenchymal transition (EMT) of CRC cells. Collectively, our study demonstrated the oncogenic roles of B7-H4 in regulating the proliferation, EMT as well as the migration of CRC cells through Wnt signaling pathway. The heightened expression of B7-H4 could serve as a prognostic marker for CRC patients.
format	article
author	Yuzhen Yin Lili Shi Jing Yang Hui Wang Hang Yang Qiang Wang
author_facet	Yuzhen Yin Lili Shi Jing Yang Hui Wang Hang Yang Qiang Wang
author_sort	Yuzhen Yin
title	B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
title_short	B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
title_full	B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
title_fullStr	B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
title_full_unstemmed	B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
title_sort	b7 family member h4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/63fc4503e31147c5ae053b6b687d2645
work_keys_str_mv	AT yuzhenyin b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells AT lilishi b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells AT jingyang b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells AT huiwang b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells AT hangyang b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells AT qiangwang b7familymemberh4inducesepithelialmesenchymaltransitionandpromotestheproliferationmigrationandinvasionofcolorectalcancercells
_version_	1718409474512781312

B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells

Ejemplares similares