Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity

Abstract The 123I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative r...

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Autores principales:	Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Yumiko Kirihara, Mitsumasa Hashimoto, Seigo Kinuya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63fd0880900a4995a57e33c602cf1634
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spelling	oai:doaj.org-article:63fd0880900a4995a57e33c602cf16342021-12-02T12:42:27ZCalibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity10.1038/s41598-020-78917-82045-2322https://doaj.org/article/63fd0880900a4995a57e33c602cf16342020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78917-8https://doaj.org/toc/2045-2322Abstract The 123I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative results differ due to variations in scintigraphic imaging procedures. Here, we created and assessed the clinical feasibility of a calibration method for 123I-MIBG imaging. The characteristics of scintigraphic imaging systems were determined using an acrylic calibration phantom to generate a multicenter phantom imaging database. Calibration factors corresponding to the scintigraphic imaging procedures were calculated from the database and applied to a clinical study. The results of this study showed that the calibrated analysis eliminated inter-institutional differences among normal individuals. In summary, our standardization methodology for 123I-MIBG scintigraphy could provide the basis for improved diagnostic precision and better outcomes for patients.Koichi OkudaKenichi NakajimaChiemi KitamuraYumiko KiriharaMitsumasa HashimotoSeigo KinuyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koichi Okuda Kenichi Nakajima Chiemi Kitamura Yumiko Kirihara Mitsumasa Hashimoto Seigo Kinuya Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
description	Abstract The 123I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative results differ due to variations in scintigraphic imaging procedures. Here, we created and assessed the clinical feasibility of a calibration method for 123I-MIBG imaging. The characteristics of scintigraphic imaging systems were determined using an acrylic calibration phantom to generate a multicenter phantom imaging database. Calibration factors corresponding to the scintigraphic imaging procedures were calculated from the database and applied to a clinical study. The results of this study showed that the calibrated analysis eliminated inter-institutional differences among normal individuals. In summary, our standardization methodology for 123I-MIBG scintigraphy could provide the basis for improved diagnostic precision and better outcomes for patients.
format	article
author	Koichi Okuda Kenichi Nakajima Chiemi Kitamura Yumiko Kirihara Mitsumasa Hashimoto Seigo Kinuya
author_facet	Koichi Okuda Kenichi Nakajima Chiemi Kitamura Yumiko Kirihara Mitsumasa Hashimoto Seigo Kinuya
author_sort	Koichi Okuda
title	Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
title_short	Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
title_full	Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
title_fullStr	Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
title_full_unstemmed	Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
title_sort	calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63fd0880900a4995a57e33c602cf1634
work_keys_str_mv	AT koichiokuda calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity AT kenichinakajima calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity AT chiemikitamura calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity AT yumikokirihara calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity AT mitsumasahashimoto calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity AT seigokinuya calibratedscintigraphicimagingproceduresimprovequantitativeassessmentofthecardiacsympatheticnerveactivity
_version_	1718393689502384128

Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity

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