Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptoma...

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Autores principales:	Mark Ferris, Rebecca Ferris, Chris Workman, Eoin O'Connor, David A Enoch, Emma Goldesgeyme, Natalie Quinnell, Parth Patel, Jo Wright, Geraldine Martell, Christine Moody, Ashley Shaw, Christopher JR Illingworth, Nicholas J Matheson, Michael P Weekes
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	COVID-19 SARS-CoV-2 healthcare worker PPE mask FFP3 Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/63fe9434a49f45088ced810afef01798
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spelling	oai:doaj.org-article:63fe9434a49f45088ced810afef017982021-12-01T14:32:57ZEfficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers10.7554/eLife.711312050-084Xe71131https://doaj.org/article/63fe9434a49f45088ced810afef017982021-11-01T00:00:00Zhttps://elifesciences.org/articles/71131https://doaj.org/toc/2050-084XBackground: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Methods: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on ‘red’ (coronavirus disease 2019, COVID-19) and ‘green’ (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. Results: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52–100% protection). Conclusions: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. Funding: Wellcome Trust, Medical Research Council, Addenbrooke’s Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.Mark FerrisRebecca FerrisChris WorkmanEoin O'ConnorDavid A EnochEmma GoldesgeymeNatalie QuinnellParth PatelJo WrightGeraldine MartellChristine MoodyAshley ShawChristopher JR IllingworthNicholas J MathesonMichael P WeekeseLife Sciences Publications LtdarticleCOVID-19SARS-CoV-2healthcare workerPPEmaskFFP3MedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 healthcare worker PPE mask FFP3 Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	COVID-19 SARS-CoV-2 healthcare worker PPE mask FFP3 Medicine R Science Q Biology (General) QH301-705.5 Mark Ferris Rebecca Ferris Chris Workman Eoin O'Connor David A Enoch Emma Goldesgeyme Natalie Quinnell Parth Patel Jo Wright Geraldine Martell Christine Moody Ashley Shaw Christopher JR Illingworth Nicholas J Matheson Michael P Weekes Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
description	Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Methods: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on ‘red’ (coronavirus disease 2019, COVID-19) and ‘green’ (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. Results: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52–100% protection). Conclusions: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. Funding: Wellcome Trust, Medical Research Council, Addenbrooke’s Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.
format	article
author	Mark Ferris Rebecca Ferris Chris Workman Eoin O'Connor David A Enoch Emma Goldesgeyme Natalie Quinnell Parth Patel Jo Wright Geraldine Martell Christine Moody Ashley Shaw Christopher JR Illingworth Nicholas J Matheson Michael P Weekes
author_facet	Mark Ferris Rebecca Ferris Chris Workman Eoin O'Connor David A Enoch Emma Goldesgeyme Natalie Quinnell Parth Patel Jo Wright Geraldine Martell Christine Moody Ashley Shaw Christopher JR Illingworth Nicholas J Matheson Michael P Weekes
author_sort	Mark Ferris
title	Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_short	Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_full	Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_fullStr	Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_full_unstemmed	Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_sort	efficacy of ffp3 respirators for prevention of sars-cov-2 infection in healthcare workers
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/63fe9434a49f45088ced810afef01798
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Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

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