CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review

Background Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disease possibly associated with the use of calcineurin inhibitors (CNI) like cyclosporine A. Case Description The case of a patient who developed severe PRES under CNI therapy shortly after heart transp...

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Autores principales:	Katharina Huenges, Philipp Kolat, Bernd Panholzer, Assad Haneya
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	heart transplantation immunusuppression rejection Surgery RD1-811
Acceso en línea:	https://doaj.org/article/6404fb2a242d4da4b5bb9bca7b846e2b
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spelling	oai:doaj.org-article:6404fb2a242d4da4b5bb9bca7b846e2b2021-11-11T00:00:03ZCSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review2194-76352194-764310.1055/s-0041-1732344https://doaj.org/article/6404fb2a242d4da4b5bb9bca7b846e2b2021-01-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732344https://doaj.org/toc/2194-7635https://doaj.org/toc/2194-7643Background Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disease possibly associated with the use of calcineurin inhibitors (CNI) like cyclosporine A. Case Description The case of a patient who developed severe PRES under CNI therapy shortly after heart transplantation is presented here. Cerebral computed tomography led to the diagnose of PRES in our patient. New therapy strategy with a quadruple immunosuppressive protocol (cortisone, mycophenolate mofetil, low-dose CNI, and a mechanistic target of rapamycin inhibitor) was started. Conclusion Under the quadruple therapy, a neurologic recovery occurred. In PRES, the presented alternative therapy strategy may lead to improving neurological conditions and preserved transplant organ functions.Katharina HuengesPhilipp KolatBernd PanholzerAssad HaneyaGeorg Thieme Verlag KGarticleheart transplantationimmunusuppressionrejectionSurgeryRD1-811ENThe Thoracic & Cardiovascular Surgeon Reports, Vol 10, Iss 01, Pp e59-e60 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart transplantation immunusuppression rejection Surgery RD1-811
spellingShingle	heart transplantation immunusuppression rejection Surgery RD1-811 Katharina Huenges Philipp Kolat Bernd Panholzer Assad Haneya CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
description	Background Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disease possibly associated with the use of calcineurin inhibitors (CNI) like cyclosporine A. Case Description The case of a patient who developed severe PRES under CNI therapy shortly after heart transplantation is presented here. Cerebral computed tomography led to the diagnose of PRES in our patient. New therapy strategy with a quadruple immunosuppressive protocol (cortisone, mycophenolate mofetil, low-dose CNI, and a mechanistic target of rapamycin inhibitor) was started. Conclusion Under the quadruple therapy, a neurologic recovery occurred. In PRES, the presented alternative therapy strategy may lead to improving neurological conditions and preserved transplant organ functions.
format	article
author	Katharina Huenges Philipp Kolat Bernd Panholzer Assad Haneya
author_facet	Katharina Huenges Philipp Kolat Bernd Panholzer Assad Haneya
author_sort	Katharina Huenges
title	CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
title_short	CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
title_full	CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
title_fullStr	CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
title_full_unstemmed	CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review
title_sort	csa-induced pres after heart transplantation—report of two cases and review
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/6404fb2a242d4da4b5bb9bca7b846e2b
work_keys_str_mv	AT katharinahuenges csainducedpresafterhearttransplantationreportoftwocasesandreview AT philippkolat csainducedpresafterhearttransplantationreportoftwocasesandreview AT berndpanholzer csainducedpresafterhearttransplantationreportoftwocasesandreview AT assadhaneya csainducedpresafterhearttransplantationreportoftwocasesandreview
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CSA-Induced PRES after Heart Transplantation—Report of Two Cases and Review

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