Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results

Abstract This retrospective study aimed to evaluate the factors affecting recurrence and visual prognosis in patients with treatment-naïve subfoveal polypoidal choroidal vasculopathy (PCV). Patients who had received three consecutive intravitreal injections of ranibizumab or aflibercept and had reac...

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Autores principales:	Joo Young Kim, Woo Young Son, Rae Young Kim, Mirinae Kim, Young Gun Park, Young-Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64056db98e2a43feb2b19bd726de1f5d
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spelling	oai:doaj.org-article:64056db98e2a43feb2b19bd726de1f5d2021-11-08T10:54:56ZRecurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results10.1038/s41598-021-00904-42045-2322https://doaj.org/article/64056db98e2a43feb2b19bd726de1f5d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00904-4https://doaj.org/toc/2045-2322Abstract This retrospective study aimed to evaluate the factors affecting recurrence and visual prognosis in patients with treatment-naïve subfoveal polypoidal choroidal vasculopathy (PCV). Patients who had received three consecutive intravitreal injections of ranibizumab or aflibercept and had reached remission were enrolled. They were divided into a group without recurrence (group 1, 26 eyes) and a group with recurrence (group 2, 121 eyes) and followed up for at least 5 years. Patients in group 2 received additional treatment for worsening. Logistic regression analysis revealed that a young age of onset (P = 0.001), high choroidal vascularity index (CVI; P = 0.019), and presence of choroidal vascular hyperpermeability (CVH; P = 0.037) were associated with a low risk of recurrence. Multiple regression analysis revealed that recurrence (P = 0.001), greatest linear dimension (P = 0.003), and polyp configuration (single or cluster; P = 0.043) were associated with final visual acuity. Patients without recurrence had a lower age of onset and higher CVI than those with recurrence, and they tended to have CVH. In addition, patients with recurrence, large lesion, and cluster polyps had worse final visual acuity than those without these factors. CVI and CVH may be used to predict recurrence of PCV.Joo Young KimWoo Young SonRae Young KimMirinae KimYoung Gun ParkYoung-Hoon ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joo Young Kim Woo Young Son Rae Young Kim Mirinae Kim Young Gun Park Young-Hoon Park Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
description	Abstract This retrospective study aimed to evaluate the factors affecting recurrence and visual prognosis in patients with treatment-naïve subfoveal polypoidal choroidal vasculopathy (PCV). Patients who had received three consecutive intravitreal injections of ranibizumab or aflibercept and had reached remission were enrolled. They were divided into a group without recurrence (group 1, 26 eyes) and a group with recurrence (group 2, 121 eyes) and followed up for at least 5 years. Patients in group 2 received additional treatment for worsening. Logistic regression analysis revealed that a young age of onset (P = 0.001), high choroidal vascularity index (CVI; P = 0.019), and presence of choroidal vascular hyperpermeability (CVH; P = 0.037) were associated with a low risk of recurrence. Multiple regression analysis revealed that recurrence (P = 0.001), greatest linear dimension (P = 0.003), and polyp configuration (single or cluster; P = 0.043) were associated with final visual acuity. Patients without recurrence had a lower age of onset and higher CVI than those with recurrence, and they tended to have CVH. In addition, patients with recurrence, large lesion, and cluster polyps had worse final visual acuity than those without these factors. CVI and CVH may be used to predict recurrence of PCV.
format	article
author	Joo Young Kim Woo Young Son Rae Young Kim Mirinae Kim Young Gun Park Young-Hoon Park
author_facet	Joo Young Kim Woo Young Son Rae Young Kim Mirinae Kim Young Gun Park Young-Hoon Park
author_sort	Joo Young Kim
title	Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
title_short	Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
title_full	Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
title_fullStr	Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
title_full_unstemmed	Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
title_sort	recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64056db98e2a43feb2b19bd726de1f5d
work_keys_str_mv	AT jooyoungkim recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults AT wooyoungson recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults AT raeyoungkim recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults AT mirinaekim recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults AT younggunpark recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults AT younghoonpark recurrenceandvisualprognosticfactorsofpolypoidalchoroidalvasculopathy5yearresults
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Recurrence and visual prognostic factors of polypoidal choroidal vasculopathy: 5-year results

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