Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia

Baoyu Wei,1 Zhaoqi Wang,1 Shihao Wu,1 John Orgah,1 Jinqiang Zhu,1 Wanshan Song2 1State Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China; 2Department of Acupun...

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Autores principales:	Wei B, Wang Z, Wu S, Orgah J, Zhu J, Song W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	vascular dementia cerebral blood flow collateral circulation pathology precaution palliation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6406c39f3e14447c9e1aadfd6bf85baf
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spelling	oai:doaj.org-article:6406c39f3e14447c9e1aadfd6bf85baf2021-12-02T18:55:10ZImproving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia1178-2021https://doaj.org/article/6406c39f3e14447c9e1aadfd6bf85baf2021-10-01T00:00:00Zhttps://www.dovepress.com/improving-collateral-circulation-a-potential-adjunctive-strategy-to-pr-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Baoyu Wei,1 Zhaoqi Wang,1 Shihao Wu,1 John Orgah,1 Jinqiang Zhu,1 Wanshan Song2 1State Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China; 2Department of Acupuncture and Cerebropathy, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, People’s Republic of ChinaCorrespondence: Wanshan Song; Jinqiang Zhu Email sws19870604@163.com; zhujinqiang1860@163.comAbstract: Vascular dementia (VaD), a cognitive disorder caused by cerebrovascular pathologies, is the most common cause of dementia in the elderly, being second only to Alzheimer’s disease. Researches have shown that adequate cerebral blood flow (CBF) is the first condition for maintaining the structural integrity and normal function of the brain, and VaD is generally considered to be resulted from neuronal loss due to reduced CBF. Collateral circulation, a compensation mechanism for CBF, provides an alternative vascular pathway for blood to reach ischemic tissues, which has been confirmed to be associated with better clinical outcomes of ischemic diseases. At present, considerable effort has been devoted to enhancing the functional prognosis of acute ischemic stroke by improving collateral circulation. Since ischemic stroke is the primary contributor to VaD, it is necessary to explore whether improving collateral circulation is beneficial to prevent or slow the progression of VaD. This article reviews the compensatory characteristics of different levels of cerebral collateral circulation, addresses the relationship between collateral circulation and VaD, and highlights that improving collateral circulation may be a potential adjunctive strategy in preventing and slowing the progression of VaD.Keywords: vascular dementia, cerebral blood flow, collateral circulation, pathology, precaution, palliationWei BWang ZWu SOrgah JZhu JSong WDove Medical Pressarticlevascular dementiacerebral blood flowcollateral circulationpathologyprecautionpalliationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3061-3067 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular dementia cerebral blood flow collateral circulation pathology precaution palliation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	vascular dementia cerebral blood flow collateral circulation pathology precaution palliation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wei B Wang Z Wu S Orgah J Zhu J Song W Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
description	Baoyu Wei,1 Zhaoqi Wang,1 Shihao Wu,1 John Orgah,1 Jinqiang Zhu,1 Wanshan Song2 1State Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China; 2Department of Acupuncture and Cerebropathy, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, People’s Republic of ChinaCorrespondence: Wanshan Song; Jinqiang Zhu Email sws19870604@163.com; zhujinqiang1860@163.comAbstract: Vascular dementia (VaD), a cognitive disorder caused by cerebrovascular pathologies, is the most common cause of dementia in the elderly, being second only to Alzheimer’s disease. Researches have shown that adequate cerebral blood flow (CBF) is the first condition for maintaining the structural integrity and normal function of the brain, and VaD is generally considered to be resulted from neuronal loss due to reduced CBF. Collateral circulation, a compensation mechanism for CBF, provides an alternative vascular pathway for blood to reach ischemic tissues, which has been confirmed to be associated with better clinical outcomes of ischemic diseases. At present, considerable effort has been devoted to enhancing the functional prognosis of acute ischemic stroke by improving collateral circulation. Since ischemic stroke is the primary contributor to VaD, it is necessary to explore whether improving collateral circulation is beneficial to prevent or slow the progression of VaD. This article reviews the compensatory characteristics of different levels of cerebral collateral circulation, addresses the relationship between collateral circulation and VaD, and highlights that improving collateral circulation may be a potential adjunctive strategy in preventing and slowing the progression of VaD.Keywords: vascular dementia, cerebral blood flow, collateral circulation, pathology, precaution, palliation
format	article
author	Wei B Wang Z Wu S Orgah J Zhu J Song W
author_facet	Wei B Wang Z Wu S Orgah J Zhu J Song W
author_sort	Wei B
title	Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
title_short	Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
title_full	Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
title_fullStr	Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
title_full_unstemmed	Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia
title_sort	improving collateral circulation: a potential adjunctive strategy to prevent or slow the progression of vascular dementia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6406c39f3e14447c9e1aadfd6bf85baf
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Improving Collateral Circulation: A Potential Adjunctive Strategy to Prevent or Slow the Progression of Vascular Dementia

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