CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection

The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination of H2B and allow Exo1-mediated resection.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ming Zeng, Laifeng Ren, Ken'Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, Cong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6407999dc3614548856bdae2f9bb63f5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6407999dc3614548856bdae2f9bb63f5
record_format	dspace
spelling	oai:doaj.org-article:6407999dc3614548856bdae2f9bb63f52021-12-02T15:35:25ZCRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection10.1038/ncomms113642041-1723https://doaj.org/article/6407999dc3614548856bdae2f9bb63f52016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11364https://doaj.org/toc/2041-1723The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination of H2B and allow Exo1-mediated resection.Ming ZengLaifeng RenKen'Ichi MizunoKonstantinos NestorasHaibin WangZizhi TangLiandi GuoDaochun KongQiwen HuQun HeLilin DuAntony M. CarrCong LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Zeng Laifeng Ren Ken'Ichi Mizuno Konstantinos Nestoras Haibin Wang Zizhi Tang Liandi Guo Daochun Kong Qiwen Hu Qun He Lilin Du Antony M. Carr Cong Liu CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
description	The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination of H2B and allow Exo1-mediated resection.
format	article
author	Ming Zeng Laifeng Ren Ken'Ichi Mizuno Konstantinos Nestoras Haibin Wang Zizhi Tang Liandi Guo Daochun Kong Qiwen Hu Qun He Lilin Du Antony M. Carr Cong Liu
author_facet	Ming Zeng Laifeng Ren Ken'Ichi Mizuno Konstantinos Nestoras Haibin Wang Zizhi Tang Liandi Guo Daochun Kong Qiwen Hu Qun He Lilin Du Antony M. Carr Cong Liu
author_sort	Ming Zeng
title	CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
title_short	CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
title_full	CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
title_fullStr	CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
title_full_unstemmed	CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
title_sort	crl4wdr70 regulates h2b monoubiquitination and facilitates exo1-dependent resection
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6407999dc3614548856bdae2f9bb63f5
work_keys_str_mv	AT mingzeng crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT laifengren crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT kenichimizuno crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT konstantinosnestoras crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT haibinwang crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT zizhitang crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT liandiguo crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT daochunkong crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT qiwenhu crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT qunhe crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT lilindu crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT antonymcarr crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection AT congliu crl4wdr70regulatesh2bmonoubiquitinationandfacilitatesexo1dependentresection
_version_	1718386536698871808

CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection

Ejemplares similares