Pattern discovery and disentanglement on relational datasets
Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack...
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Nature Portfolio
2021
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oai:doaj.org-article:64083eccb74443dabb0c1fcdff51dc8b2021-12-02T13:20:04ZPattern discovery and disentanglement on relational datasets10.1038/s41598-021-84869-42045-2322https://doaj.org/article/64083eccb74443dabb0c1fcdff51dc8b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84869-4https://doaj.org/toc/2045-2322Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack transparency and interpretability. The difficulties arise from the subtle overlapping and entanglement of functional and statistical relations at the source level. Hence, we have developed Pattern Discovery and Disentanglement System (PDD), which is able to discover explicit patterns from the data with various sizes, imbalanced groups, and screen out anomalies. We present herein four case studies on biomedical datasets to substantiate the efficacy of PDD. It improves prediction accuracy and facilitates transparent interpretation of discovered knowledge in an explicit representation framework PDD Knowledge Base that links the sources, the patterns, and individual patients. Hence, PDD promises broad and ground-breaking applications in genomic and biomedical machine learning.Andrew K. C. WongPei-Yuan ZhouZahid A. ButtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Andrew K. C. Wong Pei-Yuan Zhou Zahid A. Butt Pattern discovery and disentanglement on relational datasets |
description |
Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack transparency and interpretability. The difficulties arise from the subtle overlapping and entanglement of functional and statistical relations at the source level. Hence, we have developed Pattern Discovery and Disentanglement System (PDD), which is able to discover explicit patterns from the data with various sizes, imbalanced groups, and screen out anomalies. We present herein four case studies on biomedical datasets to substantiate the efficacy of PDD. It improves prediction accuracy and facilitates transparent interpretation of discovered knowledge in an explicit representation framework PDD Knowledge Base that links the sources, the patterns, and individual patients. Hence, PDD promises broad and ground-breaking applications in genomic and biomedical machine learning. |
format |
article |
author |
Andrew K. C. Wong Pei-Yuan Zhou Zahid A. Butt |
author_facet |
Andrew K. C. Wong Pei-Yuan Zhou Zahid A. Butt |
author_sort |
Andrew K. C. Wong |
title |
Pattern discovery and disentanglement on relational datasets |
title_short |
Pattern discovery and disentanglement on relational datasets |
title_full |
Pattern discovery and disentanglement on relational datasets |
title_fullStr |
Pattern discovery and disentanglement on relational datasets |
title_full_unstemmed |
Pattern discovery and disentanglement on relational datasets |
title_sort |
pattern discovery and disentanglement on relational datasets |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/64083eccb74443dabb0c1fcdff51dc8b |
work_keys_str_mv |
AT andrewkcwong patterndiscoveryanddisentanglementonrelationaldatasets AT peiyuanzhou patterndiscoveryanddisentanglementonrelationaldatasets AT zahidabutt patterndiscoveryanddisentanglementonrelationaldatasets |
_version_ |
1718393215136038912 |