Pattern discovery and disentanglement on relational datasets

Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack...

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Autores principales: Andrew K. C. Wong, Pei-Yuan Zhou, Zahid A. Butt
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/64083eccb74443dabb0c1fcdff51dc8b
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spelling oai:doaj.org-article:64083eccb74443dabb0c1fcdff51dc8b2021-12-02T13:20:04ZPattern discovery and disentanglement on relational datasets10.1038/s41598-021-84869-42045-2322https://doaj.org/article/64083eccb74443dabb0c1fcdff51dc8b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84869-4https://doaj.org/toc/2045-2322Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack transparency and interpretability. The difficulties arise from the subtle overlapping and entanglement of functional and statistical relations at the source level. Hence, we have developed Pattern Discovery and Disentanglement System (PDD), which is able to discover explicit patterns from the data with various sizes, imbalanced groups, and screen out anomalies. We present herein four case studies on biomedical datasets to substantiate the efficacy of PDD. It improves prediction accuracy and facilitates transparent interpretation of discovered knowledge in an explicit representation framework PDD Knowledge Base that links the sources, the patterns, and individual patients. Hence, PDD promises broad and ground-breaking applications in genomic and biomedical machine learning.Andrew K. C. WongPei-Yuan ZhouZahid A. ButtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Andrew K. C. Wong
Pei-Yuan Zhou
Zahid A. Butt
Pattern discovery and disentanglement on relational datasets
description Abstract Machine Learning has made impressive advances in many applications akin to human cognition for discernment. However, success has been limited in the areas of relational datasets, particularly for data with low volume, imbalanced groups, and mislabeled cases, with outputs that typically lack transparency and interpretability. The difficulties arise from the subtle overlapping and entanglement of functional and statistical relations at the source level. Hence, we have developed Pattern Discovery and Disentanglement System (PDD), which is able to discover explicit patterns from the data with various sizes, imbalanced groups, and screen out anomalies. We present herein four case studies on biomedical datasets to substantiate the efficacy of PDD. It improves prediction accuracy and facilitates transparent interpretation of discovered knowledge in an explicit representation framework PDD Knowledge Base that links the sources, the patterns, and individual patients. Hence, PDD promises broad and ground-breaking applications in genomic and biomedical machine learning.
format article
author Andrew K. C. Wong
Pei-Yuan Zhou
Zahid A. Butt
author_facet Andrew K. C. Wong
Pei-Yuan Zhou
Zahid A. Butt
author_sort Andrew K. C. Wong
title Pattern discovery and disentanglement on relational datasets
title_short Pattern discovery and disentanglement on relational datasets
title_full Pattern discovery and disentanglement on relational datasets
title_fullStr Pattern discovery and disentanglement on relational datasets
title_full_unstemmed Pattern discovery and disentanglement on relational datasets
title_sort pattern discovery and disentanglement on relational datasets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/64083eccb74443dabb0c1fcdff51dc8b
work_keys_str_mv AT andrewkcwong patterndiscoveryanddisentanglementonrelationaldatasets
AT peiyuanzhou patterndiscoveryanddisentanglementonrelationaldatasets
AT zahidabutt patterndiscoveryanddisentanglementonrelationaldatasets
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