Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor

BACKGROUND AND OBJECTIVE: Corticosteroids has been used for pregnant women for fetal lung maturation but there are many controversies about their effect and side effect, the aim of this study was to determine the effect of bethamethasone on the serum marker of infection in women at high risk for pre...

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Autores principales:	M Javadian Kootenaee, Z Bouzari, Z Basirat, A Halakou
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	betamethasone preterm labor cpr esr wbc Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/640a3fbf19c34ed6a4d396c35690d6be
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spelling	oai:doaj.org-article:640a3fbf19c34ed6a4d396c35690d6be2021-11-10T09:00:22ZEffect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor1561-41072251-7170https://doaj.org/article/640a3fbf19c34ed6a4d396c35690d6be2010-06-01T00:00:00Zhttp://jbums.org/article-1-3468-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Corticosteroids has been used for pregnant women for fetal lung maturation but there are many controversies about their effect and side effect, the aim of this study was to determine the effect of bethamethasone on the serum marker of infection in women at high risk for preterm delivery. METHODS: This prospective study was performed on 50 pregnant women at risk for preterm labor between 28-34 weeks of gestation who were treated by betamethasone (12 mg every 12 hours for 2 doses) for enhancement of fetal lung maturation in Shahid Yahyanejad hospital in Babol. Blood test for WBC, ESR and CRP were drawn before Bethamethasone injection, 2 hours after injection and second and third days after injection. The data were compared.FINDINGS: Mean gestational age was 31.9±2.4 weeks. The mean WBC (396±81) (p=0.000), neutrophil (473±109) (p=0.000) and ESR (1.8±0.6) (p=0.008) after treatment was significantly higher than before treatment. But mean of lymphocyte before and after treatment showed no significant difference. CRP value was increased significantly after treatment (p=0.009).CONCLUSION: The results of this study showed that antenatal betamethasone therapy causes a transient increase in maternal serum indicators of infection but returns to basic level soon.M Javadian KootenaeeZ Bouzari,Z BasiratA HalakouBabol University of Medical Sciencesarticlebetamethasonepreterm laborcpresrwbcMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 2, Pp 19-23 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	betamethasone preterm labor cpr esr wbc Medicine R Medicine (General) R5-920
spellingShingle	betamethasone preterm labor cpr esr wbc Medicine R Medicine (General) R5-920 M Javadian Kootenaee Z Bouzari, Z Basirat A Halakou Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
description	BACKGROUND AND OBJECTIVE: Corticosteroids has been used for pregnant women for fetal lung maturation but there are many controversies about their effect and side effect, the aim of this study was to determine the effect of bethamethasone on the serum marker of infection in women at high risk for preterm delivery. METHODS: This prospective study was performed on 50 pregnant women at risk for preterm labor between 28-34 weeks of gestation who were treated by betamethasone (12 mg every 12 hours for 2 doses) for enhancement of fetal lung maturation in Shahid Yahyanejad hospital in Babol. Blood test for WBC, ESR and CRP were drawn before Bethamethasone injection, 2 hours after injection and second and third days after injection. The data were compared.FINDINGS: Mean gestational age was 31.9±2.4 weeks. The mean WBC (396±81) (p=0.000), neutrophil (473±109) (p=0.000) and ESR (1.8±0.6) (p=0.008) after treatment was significantly higher than before treatment. But mean of lymphocyte before and after treatment showed no significant difference. CRP value was increased significantly after treatment (p=0.009).CONCLUSION: The results of this study showed that antenatal betamethasone therapy causes a transient increase in maternal serum indicators of infection but returns to basic level soon.
format	article
author	M Javadian Kootenaee Z Bouzari, Z Basirat A Halakou
author_facet	M Javadian Kootenaee Z Bouzari, Z Basirat A Halakou
author_sort	M Javadian Kootenaee
title	Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
title_short	Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
title_full	Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
title_fullStr	Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
title_full_unstemmed	Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor
title_sort	effect of betamethasone on acute phase reactant serum markers in pregnant women at risk of preterm labor
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/640a3fbf19c34ed6a4d396c35690d6be
work_keys_str_mv	AT mjavadiankootenaee effectofbetamethasoneonacutephasereactantserummarkersinpregnantwomenatriskofpretermlabor AT zbouzari effectofbetamethasoneonacutephasereactantserummarkersinpregnantwomenatriskofpretermlabor AT zbasirat effectofbetamethasoneonacutephasereactantserummarkersinpregnantwomenatriskofpretermlabor AT ahalakou effectofbetamethasoneonacutephasereactantserummarkersinpregnantwomenatriskofpretermlabor
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Effect of Betamethasone on Acute Phase Reactant Serum Markers in Pregnant Women at Risk of Preterm Labor

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