Gliotoxin, a Known Virulence Factor in the Major Human Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>, Is Also Biosynthesized by Its Nonpathogenic Relative <italic toggle="yes">Aspergillus fischeri</italic>

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>, Is Also Biosynthesized by Its Nonpathogenic Relative <italic toggle="yes">Aspergillus fischeri</italic>

ABSTRACT Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites, such as gliotoxin. Gliotoxin is known to inhibit the host immune response, and genetic mutants that inact...

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Autores principales: Sonja L. Knowles, Matthew E. Mead, Lilian Pereira Silva, Huzefa A. Raja, Jacob L. Steenwyk, Gustavo H. Goldman, Nicholas H. Oberlies, Antonis Rokas
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
fungal pathogenesis
secondary metabolism
gliotoxin
specialized metabolism
evolution of virulence
laeA
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/640b52c900b54ab28608595e634c7262
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