Widespread disruption of functional brain organization in early-onset Alzheimer's disease.

Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onse...

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Autores principales:	Sofie M Adriaanse, Maja A A Binnewijzend, Rik Ossenkoppele, Betty M Tijms, Wiesje M van der Flier, Teddy Koene, Lieke L Smits, Alle Meije Wink, Philip Scheltens, Bart N M van Berckel, Frederik Barkhof
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/641a6063676f4fb1bad1d7f5f12e9361
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spelling	oai:doaj.org-article:641a6063676f4fb1bad1d7f5f12e93612021-11-25T06:06:28ZWidespread disruption of functional brain organization in early-onset Alzheimer's disease.1932-620310.1371/journal.pone.0102995https://doaj.org/article/641a6063676f4fb1bad1d7f5f12e93612014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25080229/?tool=EBIhttps://doaj.org/toc/1932-6203Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onset and late-onset AD patients. Resting-state fMRI scans of 20 early-onset (<65 years old), 28 late-onset (≥65 years old) AD patients and 15 "young" (<65 years old) and 31 "old" (≥65 years old) age-matched controls were available. Resting-state network-masks were used to create subject-specific maps. Group differences were examined using a non-parametric permutation test, accounting for gray-matter. Performance on five cognitive domains were used in a correlation analysis with functional connectivity in AD patients. Functional connectivity was not different in any of the RSNs when comparing the two control groups (young vs. old controls), which implies that there is no general effect of aging on functional connectivity. Functional connectivity in early-onset AD was lower in all networks compared to age-matched controls, where late-onset AD showed lower functional connectivity in the default-mode network. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Across patients, an association of functional connectivity of the default mode network was found with visuoconstruction. Functional connectivity of the right dorsal visual system was associated with attention across patients. In late-onset AD patients alone, higher functional connectivity of the sensory-motor system was associated with poorer memory performance. Functional brain organization was more widely disrupted in early-onset AD when compared to late-onset AD. This could possibly explain different clinical profiles, although more research into the relationship of functional connectivity and cognitive performance is needed.Sofie M AdriaanseMaja A A BinnewijzendRik OssenkoppeleBetty M TijmsWiesje M van der FlierTeddy KoeneLieke L SmitsAlle Meije WinkPhilip ScheltensBart N M van BerckelFrederik BarkhofPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102995 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sofie M Adriaanse Maja A A Binnewijzend Rik Ossenkoppele Betty M Tijms Wiesje M van der Flier Teddy Koene Lieke L Smits Alle Meije Wink Philip Scheltens Bart N M van Berckel Frederik Barkhof Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
description	Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onset and late-onset AD patients. Resting-state fMRI scans of 20 early-onset (<65 years old), 28 late-onset (≥65 years old) AD patients and 15 "young" (<65 years old) and 31 "old" (≥65 years old) age-matched controls were available. Resting-state network-masks were used to create subject-specific maps. Group differences were examined using a non-parametric permutation test, accounting for gray-matter. Performance on five cognitive domains were used in a correlation analysis with functional connectivity in AD patients. Functional connectivity was not different in any of the RSNs when comparing the two control groups (young vs. old controls), which implies that there is no general effect of aging on functional connectivity. Functional connectivity in early-onset AD was lower in all networks compared to age-matched controls, where late-onset AD showed lower functional connectivity in the default-mode network. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Across patients, an association of functional connectivity of the default mode network was found with visuoconstruction. Functional connectivity of the right dorsal visual system was associated with attention across patients. In late-onset AD patients alone, higher functional connectivity of the sensory-motor system was associated with poorer memory performance. Functional brain organization was more widely disrupted in early-onset AD when compared to late-onset AD. This could possibly explain different clinical profiles, although more research into the relationship of functional connectivity and cognitive performance is needed.
format	article
author	Sofie M Adriaanse Maja A A Binnewijzend Rik Ossenkoppele Betty M Tijms Wiesje M van der Flier Teddy Koene Lieke L Smits Alle Meije Wink Philip Scheltens Bart N M van Berckel Frederik Barkhof
author_facet	Sofie M Adriaanse Maja A A Binnewijzend Rik Ossenkoppele Betty M Tijms Wiesje M van der Flier Teddy Koene Lieke L Smits Alle Meije Wink Philip Scheltens Bart N M van Berckel Frederik Barkhof
author_sort	Sofie M Adriaanse
title	Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
title_short	Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
title_full	Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
title_fullStr	Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
title_full_unstemmed	Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
title_sort	widespread disruption of functional brain organization in early-onset alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/641a6063676f4fb1bad1d7f5f12e9361
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Widespread disruption of functional brain organization in early-onset Alzheimer's disease.

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