Magnetic resonance spectroscopy in Alzheimer’s disease
Jonathan Graff-Radford,1 Kejal Kantarci21Department of Neurology, 2Department of Radiology, Mayo Clinic, Rochester, MN, USAAbstract: Aging is the primary risk factor for dementia. With increasing life expectancy and aging populations worldwide, dementia is becoming one of the significant public heal...
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Dove Medical Press
2013
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oai:doaj.org-article:641a62ce47cf4e26bb4a41e7eddbcb552021-12-02T05:36:37ZMagnetic resonance spectroscopy in Alzheimer’s disease1176-63281178-2021https://doaj.org/article/641a62ce47cf4e26bb4a41e7eddbcb552013-05-01T00:00:00Zhttp://www.dovepress.com/magnetic-resonance-spectroscopy-in-alzheimerrsquos-disease-a13067https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jonathan Graff-Radford,1 Kejal Kantarci21Department of Neurology, 2Department of Radiology, Mayo Clinic, Rochester, MN, USAAbstract: Aging is the primary risk factor for dementia. With increasing life expectancy and aging populations worldwide, dementia is becoming one of the significant public health problems of the century. The most common pathology underlying dementia in older adults is Alzheimer’s disease. Proton magnetic resonance spectroscopy (MRS) may provide a window into the biochemical changes associated with the loss of neuronal integrity and other neurodegenerative pathology that involve the brain before the manifestations of cognitive impairment in patients who are at risk for Alzheimer’s disease. This review focuses on proton MRS studies in normal aging, mild cognitive impairment, and dementia, and how proton MRS metabolite levels may be potential biomarkers for early diagnosis of dementia-related pathologic changes in the brain.Keywords: Alzheimer’s disease, magnetic resonance spectroscopy, mild cognitive impairmentGraff-Radford JKantarci KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 687-696 (2013) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Graff-Radford J Kantarci K Magnetic resonance spectroscopy in Alzheimer’s disease |
| description |
Jonathan Graff-Radford,1 Kejal Kantarci21Department of Neurology, 2Department of Radiology, Mayo Clinic, Rochester, MN, USAAbstract: Aging is the primary risk factor for dementia. With increasing life expectancy and aging populations worldwide, dementia is becoming one of the significant public health problems of the century. The most common pathology underlying dementia in older adults is Alzheimer’s disease. Proton magnetic resonance spectroscopy (MRS) may provide a window into the biochemical changes associated with the loss of neuronal integrity and other neurodegenerative pathology that involve the brain before the manifestations of cognitive impairment in patients who are at risk for Alzheimer’s disease. This review focuses on proton MRS studies in normal aging, mild cognitive impairment, and dementia, and how proton MRS metabolite levels may be potential biomarkers for early diagnosis of dementia-related pathologic changes in the brain.Keywords: Alzheimer’s disease, magnetic resonance spectroscopy, mild cognitive impairment |
| format |
article |
| author |
Graff-Radford J Kantarci K |
| author_facet |
Graff-Radford J Kantarci K |
| author_sort |
Graff-Radford J |
| title |
Magnetic resonance spectroscopy in Alzheimer’s disease |
| title_short |
Magnetic resonance spectroscopy in Alzheimer’s disease |
| title_full |
Magnetic resonance spectroscopy in Alzheimer’s disease |
| title_fullStr |
Magnetic resonance spectroscopy in Alzheimer’s disease |
| title_full_unstemmed |
Magnetic resonance spectroscopy in Alzheimer’s disease |
| title_sort |
magnetic resonance spectroscopy in alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/641a62ce47cf4e26bb4a41e7eddbcb55 |
| work_keys_str_mv |
AT graffradfordj magneticresonancespectroscopyinalzheimerrsquosdisease AT kantarcik magneticresonancespectroscopyinalzheimerrsquosdisease |
| _version_ |
1718400300925059072 |