Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plas...

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Autores principales: Julie Jézéquel, Emily M. Johansson, Julien P. Dupuis, Véronique Rogemond, Hélène Gréa, Blanka Kellermayer, Nora Hamdani, Emmanuel Le Guen, Corentin Rabu, Marilyn Lepleux, Marianna Spatola, Elodie Mathias, Delphine Bouchet, Amy J. Ramsey, Robert H. Yolken, Ryad Tamouza, Josep Dalmau, Jérôme Honnorat, Marion Leboyer, Laurent Groc
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/641d0c18165948329f6f6c33b654b354
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spelling oai:doaj.org-article:641d0c18165948329f6f6c33b654b3542021-12-02T17:06:01ZDynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients10.1038/s41467-017-01700-32041-1723https://doaj.org/article/641d0c18165948329f6f6c33b654b3542017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01700-3https://doaj.org/toc/2041-1723Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plasticity.Julie JézéquelEmily M. JohanssonJulien P. DupuisVéronique RogemondHélène GréaBlanka KellermayerNora HamdaniEmmanuel Le GuenCorentin RabuMarilyn LepleuxMarianna SpatolaElodie MathiasDelphine BouchetAmy J. RamseyRobert H. YolkenRyad TamouzaJosep DalmauJérôme HonnoratMarion LeboyerLaurent GrocNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julie Jézéquel
Emily M. Johansson
Julien P. Dupuis
Véronique Rogemond
Hélène Gréa
Blanka Kellermayer
Nora Hamdani
Emmanuel Le Guen
Corentin Rabu
Marilyn Lepleux
Marianna Spatola
Elodie Mathias
Delphine Bouchet
Amy J. Ramsey
Robert H. Yolken
Ryad Tamouza
Josep Dalmau
Jérôme Honnorat
Marion Leboyer
Laurent Groc
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
description Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plasticity.
format article
author Julie Jézéquel
Emily M. Johansson
Julien P. Dupuis
Véronique Rogemond
Hélène Gréa
Blanka Kellermayer
Nora Hamdani
Emmanuel Le Guen
Corentin Rabu
Marilyn Lepleux
Marianna Spatola
Elodie Mathias
Delphine Bouchet
Amy J. Ramsey
Robert H. Yolken
Ryad Tamouza
Josep Dalmau
Jérôme Honnorat
Marion Leboyer
Laurent Groc
author_facet Julie Jézéquel
Emily M. Johansson
Julien P. Dupuis
Véronique Rogemond
Hélène Gréa
Blanka Kellermayer
Nora Hamdani
Emmanuel Le Guen
Corentin Rabu
Marilyn Lepleux
Marianna Spatola
Elodie Mathias
Delphine Bouchet
Amy J. Ramsey
Robert H. Yolken
Ryad Tamouza
Josep Dalmau
Jérôme Honnorat
Marion Leboyer
Laurent Groc
author_sort Julie Jézéquel
title Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
title_short Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
title_full Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
title_fullStr Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
title_full_unstemmed Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
title_sort dynamic disorganization of synaptic nmda receptors triggered by autoantibodies from psychotic patients
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/641d0c18165948329f6f6c33b654b354
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