Intramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron(III) catalyst

The direct substitution of the OH group of stereogenic alcohols are reported rarely in literature. Here, the authors demonstrate direct substitution of both secondary and tertiary alcohols with chirality transfer leading to enantioenriched 5-membered, 6-membered and aryl-fused 6-membered heterocycli...

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Autores principales: Rahul A. Watile, Anon Bunrit, Jèssica Margalef, Sunisa Akkarasamiyo, Rabia Ayub, Emi Lagerspets, Srijit Biswas, Timo Repo, Joseph S. M. Samec
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/642177931c6547d3ba77fdf91901c007
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Sumario:The direct substitution of the OH group of stereogenic alcohols are reported rarely in literature. Here, the authors demonstrate direct substitution of both secondary and tertiary alcohols with chirality transfer leading to enantioenriched 5-membered, 6-membered and aryl-fused 6-membered heterocyclic compounds.