Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U)
AS is an important pathological basis of cardiovascular disease. It has been reported that miRNAs are involved in almost all steps of AS, including the injury and dysfunction of endothelial cells and vascular smooth muscle cells. This work was designed to elucidate the biological functions of miR-51...
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Autores principales: | Peipei Ge, Mingxiao Gao, Juan Du, Jingbin Yu, Lei Zhang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Taylor & Francis Group
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/64219f205cd24bfa8342f7c75b02d111 |
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