PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES

The acid-base interaction between a polyelectrolyte and an ionisable drug could lead to the formation ionic complexes. The resulting physicochemical properties of such nanostructures could reflect changes in solubility, stability and drug-release pattern. This study was aimed to establish if diclofe...

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Autores principales:	Yolima BAENA A., Rubén H. MANZO, Luisa F. PONCE D'LEÓN Q.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	Complex diclofenac polymethylmethacrylate solubility ion pair. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/6423aafd4e9d4db0b6117346f5d6995a
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spelling	oai:doaj.org-article:6423aafd4e9d4db0b6117346f5d6995a2021-11-19T04:13:08ZPREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES0121-40042145-2660https://doaj.org/article/6423aafd4e9d4db0b6117346f5d6995a2011-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10654https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The acid-base interaction between a polyelectrolyte and an ionisable drug could lead to the formation ionic complexes. The resulting physicochemical properties of such nanostructures could reflect changes in solubility, stability and drug-release pattern. This study was aimed to establish if diclofenac solubility could be modified by the formation of Eudragit® E and diclofenac polyelectrolyte drug complexes, which were prepared through the solvent evaporation method. The solid state was characterized by infrared spectroscopy and X-ray powder diffraction, and solubility was determined. The results suggested that complexes were formed in each case, they were called: EuD50, EuD50Cl10, EuD50Cl25, and EuD50Cl35. The drug apparent solubility presented values 431 and 1,498 times higher for EuD50Cl25 and EuD50Cl35 complexes respectively using water as solvent, and 3,674 and 10,412 times higher in physiological solution compared with free drug. It was concluded that the complexes have different solubility to the one of the parent drug and, therefore, they showed potential applications in the design of homogeneous liquid dosage forms.Yolima BAENA A.Rubén H. MANZOLuisa F. PONCE D'LEÓN Q.Universidad de AntioquiaarticleComplexdiclofenacpolymethylmethacrylatesolubilityion pair.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 3 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Complex diclofenac polymethylmethacrylate solubility ion pair. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Complex diclofenac polymethylmethacrylate solubility ion pair. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Yolima BAENA A. Rubén H. MANZO Luisa F. PONCE D'LEÓN Q. PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
description	The acid-base interaction between a polyelectrolyte and an ionisable drug could lead to the formation ionic complexes. The resulting physicochemical properties of such nanostructures could reflect changes in solubility, stability and drug-release pattern. This study was aimed to establish if diclofenac solubility could be modified by the formation of Eudragit® E and diclofenac polyelectrolyte drug complexes, which were prepared through the solvent evaporation method. The solid state was characterized by infrared spectroscopy and X-ray powder diffraction, and solubility was determined. The results suggested that complexes were formed in each case, they were called: EuD50, EuD50Cl10, EuD50Cl25, and EuD50Cl35. The drug apparent solubility presented values 431 and 1,498 times higher for EuD50Cl25 and EuD50Cl35 complexes respectively using water as solvent, and 3,674 and 10,412 times higher in physiological solution compared with free drug. It was concluded that the complexes have different solubility to the one of the parent drug and, therefore, they showed potential applications in the design of homogeneous liquid dosage forms.
format	article
author	Yolima BAENA A. Rubén H. MANZO Luisa F. PONCE D'LEÓN Q.
author_facet	Yolima BAENA A. Rubén H. MANZO Luisa F. PONCE D'LEÓN Q.
author_sort	Yolima BAENA A.
title	PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
title_short	PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
title_full	PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
title_fullStr	PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
title_full_unstemmed	PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES
title_sort	preparation and physicochemical characterization of some polyelectrolyte-diclofenac complexes
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/6423aafd4e9d4db0b6117346f5d6995a
work_keys_str_mv	AT yolimabaenaa preparationandphysicochemicalcharacterizationofsomepolyelectrolytediclofenaccomplexes AT rubenhmanzo preparationandphysicochemicalcharacterizationofsomepolyelectrolytediclofenaccomplexes AT luisafponcedleonq preparationandphysicochemicalcharacterizationofsomepolyelectrolytediclofenaccomplexes
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PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SOME POLYELECTROLYTE-DICLOFENAC COMPLEXES

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