Intra-bundle contractions enable extensile properties of active actin networks

Abstract The cellular cortex is a dynamic and contractile actomyosin network modulated by actin-binding proteins. We reconstituted a minimal cortex adhered to a model cell membrane mimicking two processes mediated by the motor protein myosin: contractility and high turnover of actin monomers. Myosin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	P. Bleicher, T. Nast-Kolb, A. Sciortino, Y. A. de la Trobe, T. Pokrant, J. Faix, A. R. Bausch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6424f8346dc7485f8b9377620f545e40
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6424f8346dc7485f8b9377620f545e40
record_format	dspace
spelling	oai:doaj.org-article:6424f8346dc7485f8b9377620f545e402021-12-02T10:48:32ZIntra-bundle contractions enable extensile properties of active actin networks10.1038/s41598-021-81601-02045-2322https://doaj.org/article/6424f8346dc7485f8b9377620f545e402021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81601-0https://doaj.org/toc/2045-2322Abstract The cellular cortex is a dynamic and contractile actomyosin network modulated by actin-binding proteins. We reconstituted a minimal cortex adhered to a model cell membrane mimicking two processes mediated by the motor protein myosin: contractility and high turnover of actin monomers. Myosin reorganized these networks by extensile intra‑bundle contractions leading to an altered growth mechanism. Hereby, stress within tethered bundles induced nicking of filaments followed by repair via incorporation of free monomers. This mechanism was able to break the symmetry of the previously disordered network resulting in the generation of extensile clusters, reminiscent of structures found within cells.P. BleicherT. Nast-KolbA. SciortinoY. A. de la TrobeT. PokrantJ. FaixA. R. BauschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P. Bleicher T. Nast-Kolb A. Sciortino Y. A. de la Trobe T. Pokrant J. Faix A. R. Bausch Intra-bundle contractions enable extensile properties of active actin networks
description	Abstract The cellular cortex is a dynamic and contractile actomyosin network modulated by actin-binding proteins. We reconstituted a minimal cortex adhered to a model cell membrane mimicking two processes mediated by the motor protein myosin: contractility and high turnover of actin monomers. Myosin reorganized these networks by extensile intra‑bundle contractions leading to an altered growth mechanism. Hereby, stress within tethered bundles induced nicking of filaments followed by repair via incorporation of free monomers. This mechanism was able to break the symmetry of the previously disordered network resulting in the generation of extensile clusters, reminiscent of structures found within cells.
format	article
author	P. Bleicher T. Nast-Kolb A. Sciortino Y. A. de la Trobe T. Pokrant J. Faix A. R. Bausch
author_facet	P. Bleicher T. Nast-Kolb A. Sciortino Y. A. de la Trobe T. Pokrant J. Faix A. R. Bausch
author_sort	P. Bleicher
title	Intra-bundle contractions enable extensile properties of active actin networks
title_short	Intra-bundle contractions enable extensile properties of active actin networks
title_full	Intra-bundle contractions enable extensile properties of active actin networks
title_fullStr	Intra-bundle contractions enable extensile properties of active actin networks
title_full_unstemmed	Intra-bundle contractions enable extensile properties of active actin networks
title_sort	intra-bundle contractions enable extensile properties of active actin networks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6424f8346dc7485f8b9377620f545e40
work_keys_str_mv	AT pbleicher intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT tnastkolb intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT asciortino intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT yadelatrobe intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT tpokrant intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT jfaix intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks AT arbausch intrabundlecontractionsenableextensilepropertiesofactiveactinnetworks
_version_	1718396651034378240

Intra-bundle contractions enable extensile properties of active actin networks

Ejemplares similares