Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence

Abstract Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key factor contributing to this problem is the long-lasting nature of drug-seeking behavior associated with opioid use. We modeled this behavior in...

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Autores principales:	Mary Tresa Zanda, Gabriele Floris, Stephanie E. Sillivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/642541cecae04f93bdf2c08c29bb4dea
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spelling	oai:doaj.org-article:642541cecae04f93bdf2c08c29bb4dea2021-12-02T17:03:50ZDrug-associated cues and drug dosage contribute to increased opioid seeking after abstinence10.1038/s41598-021-94214-42045-2322https://doaj.org/article/642541cecae04f93bdf2c08c29bb4dea2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94214-4https://doaj.org/toc/2045-2322Abstract Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key factor contributing to this problem is the long-lasting nature of drug-seeking behavior associated with opioid use. We modeled this behavior in a rat drug self-administration paradigm in which drug-seeking is higher after extended abstinence than during the acute abstinence phase. The goal of this study was to determine the contribution of discrete or discriminative drug cues and drug dosage to time-dependent increases in drug-seeking. We examined heroin-seeking after 2 or 21 days of abstinence from two different self-administration cue-context environments using high or low doses of heroin and matched animals for their drug intake history. When lower dosages of heroin are used in discriminative or discrete cue protocols, drug intake history contributed to drug-seeking after abstinence, regardless of abstinence length. Incubation of opioid craving at higher dosages paired with discrete drug cues was not dependent on drug intake. Thus, interactions between drug cues and drug dosage uniquely determined conditions permissible for incubation of heroin craving. Understanding factors that contribute to long-lasting opioid-seeking can provide essential insight into environmental stimuli and drug-taking patterns that promote relapse after periods of successful abstinence.Mary Tresa ZandaGabriele FlorisStephanie E. SillivanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mary Tresa Zanda Gabriele Floris Stephanie E. Sillivan Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
description	Abstract Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key factor contributing to this problem is the long-lasting nature of drug-seeking behavior associated with opioid use. We modeled this behavior in a rat drug self-administration paradigm in which drug-seeking is higher after extended abstinence than during the acute abstinence phase. The goal of this study was to determine the contribution of discrete or discriminative drug cues and drug dosage to time-dependent increases in drug-seeking. We examined heroin-seeking after 2 or 21 days of abstinence from two different self-administration cue-context environments using high or low doses of heroin and matched animals for their drug intake history. When lower dosages of heroin are used in discriminative or discrete cue protocols, drug intake history contributed to drug-seeking after abstinence, regardless of abstinence length. Incubation of opioid craving at higher dosages paired with discrete drug cues was not dependent on drug intake. Thus, interactions between drug cues and drug dosage uniquely determined conditions permissible for incubation of heroin craving. Understanding factors that contribute to long-lasting opioid-seeking can provide essential insight into environmental stimuli and drug-taking patterns that promote relapse after periods of successful abstinence.
format	article
author	Mary Tresa Zanda Gabriele Floris Stephanie E. Sillivan
author_facet	Mary Tresa Zanda Gabriele Floris Stephanie E. Sillivan
author_sort	Mary Tresa Zanda
title	Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
title_short	Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
title_full	Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
title_fullStr	Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
title_full_unstemmed	Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
title_sort	drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/642541cecae04f93bdf2c08c29bb4dea
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Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence

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