Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this...

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Autores principales:	Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Kan Wang, Xin Sheng, Ali Amin Al Olama, Fredrick R. Schumacher, Sue A. Ingles, Koveela Govindasami, Sara Benlloch, Sonja I. Berndt, Demetrius Albanes, Stella Koutros, Kenneth Muir, Victoria L. Stevens, Susan M. Gapstur, Catherine M. Tangen, Jyotsna Batra, Judith Clements, Henrik Gronberg, Nora Pashayan, Johanna Schleutker, Alicja Wolk, Catharine West, Lorelei Mucci, Peter Kraft, Géraldine Cancel-Tassin, Karina D. Sorensen, Lovise Maehle, Eli M. Grindedal, Sara S. Strom, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Barry Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Jeanette T. Bensen, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago-Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa A. Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau, Daniel J. Schaid, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Fredrik Wiklund, Stephen J. Chanock, Douglas F. Easton, Rosalind A. Eeles, Zsofia Kote-Jarai, David V. Conti, Christopher A. Haiman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6428a658c0984d8c9397b44cf7b6287f
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spelling	oai:doaj.org-article:6428a658c0984d8c9397b44cf7b6287f2021-12-02T17:33:04ZGermline variation at 8q24 and prostate cancer risk in men of European ancestry10.1038/s41467-018-06863-12041-1723https://doaj.org/article/6428a658c0984d8c9397b44cf7b6287f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06863-1https://doaj.org/toc/2041-1723Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.Marco MatejcicEdward J. SaundersTokhir DadaevMark N. BrookKan WangXin ShengAli Amin Al OlamaFredrick R. SchumacherSue A. InglesKoveela GovindasamiSara BenllochSonja I. BerndtDemetrius AlbanesStella KoutrosKenneth MuirVictoria L. StevensSusan M. GapsturCatherine M. TangenJyotsna BatraJudith ClementsHenrik GronbergNora PashayanJohanna SchleutkerAlicja WolkCatharine WestLorelei MucciPeter KraftGéraldine Cancel-TassinKarina D. SorensenLovise MaehleEli M. GrindedalSara S. StromDavid E. NealFreddie C. HamdyJenny L. DonovanRuth C. TravisRobert J. HamiltonBarry RosensteinYong-Jie LuGraham G. GilesAdam S. KibelAna VegaJeanette T. BensenManolis KogevinasKathryn L. PenneyJong Y. ParkJanet L. StanfordCezary CybulskiBørge G. NordestgaardHermann BrennerChristiane MaierJeri KimManuel R. TeixeiraSusan L. NeuhausenKim De RuyckAzad RazackLisa F. NewcombDavor LesselRadka KanevaNawaid UsmaniFrank ClaessensPaul A. TownsendManuela Gago-DominguezMonique J. RoobolFlorence MenegauxKay-Tee KhawLisa A. Cannon-AlbrightHardev PandhaStephen N. ThibodeauDaniel J. SchaidThe PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) ConsortiumFredrik WiklundStephen J. ChanockDouglas F. EastonRosalind A. EelesZsofia Kote-JaraiDavid V. ContiChristopher A. HaimanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Matejcic Edward J. Saunders Tokhir Dadaev Mark N. Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R. Schumacher Sue A. Ingles Koveela Govindasami Sara Benlloch Sonja I. Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L. Stevens Susan M. Gapstur Catherine M. Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D. Sorensen Lovise Maehle Eli M. Grindedal Sara S. Strom David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Barry Rosenstein Yong-Jie Lu Graham G. Giles Adam S. Kibel Ana Vega Jeanette T. Bensen Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanford Cezary Cybulski Børge G. Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Manuela Gago-Dominguez Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa A. Cannon-Albright Hardev Pandha Stephen N. Thibodeau Daniel J. Schaid The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium Fredrik Wiklund Stephen J. Chanock Douglas F. Easton Rosalind A. Eeles Zsofia Kote-Jarai David V. Conti Christopher A. Haiman Germline variation at 8q24 and prostate cancer risk in men of European ancestry
description	Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.
format	article
author	Marco Matejcic Edward J. Saunders Tokhir Dadaev Mark N. Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R. Schumacher Sue A. Ingles Koveela Govindasami Sara Benlloch Sonja I. Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L. Stevens Susan M. Gapstur Catherine M. Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D. Sorensen Lovise Maehle Eli M. Grindedal Sara S. Strom David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Barry Rosenstein Yong-Jie Lu Graham G. Giles Adam S. Kibel Ana Vega Jeanette T. Bensen Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanford Cezary Cybulski Børge G. Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Manuela Gago-Dominguez Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa A. Cannon-Albright Hardev Pandha Stephen N. Thibodeau Daniel J. Schaid The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium Fredrik Wiklund Stephen J. Chanock Douglas F. Easton Rosalind A. Eeles Zsofia Kote-Jarai David V. Conti Christopher A. Haiman
author_facet	Marco Matejcic Edward J. Saunders Tokhir Dadaev Mark N. Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R. Schumacher Sue A. Ingles Koveela Govindasami Sara Benlloch Sonja I. Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L. Stevens Susan M. Gapstur Catherine M. Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D. Sorensen Lovise Maehle Eli M. Grindedal Sara S. Strom David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Barry Rosenstein Yong-Jie Lu Graham G. Giles Adam S. Kibel Ana Vega Jeanette T. Bensen Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanford Cezary Cybulski Børge G. Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Manuela Gago-Dominguez Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa A. Cannon-Albright Hardev Pandha Stephen N. Thibodeau Daniel J. Schaid The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium Fredrik Wiklund Stephen J. Chanock Douglas F. Easton Rosalind A. Eeles Zsofia Kote-Jarai David V. Conti Christopher A. Haiman
author_sort	Marco Matejcic
title	Germline variation at 8q24 and prostate cancer risk in men of European ancestry
title_short	Germline variation at 8q24 and prostate cancer risk in men of European ancestry
title_full	Germline variation at 8q24 and prostate cancer risk in men of European ancestry
title_fullStr	Germline variation at 8q24 and prostate cancer risk in men of European ancestry
title_full_unstemmed	Germline variation at 8q24 and prostate cancer risk in men of European ancestry
title_sort	germline variation at 8q24 and prostate cancer risk in men of european ancestry
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6428a658c0984d8c9397b44cf7b6287f
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Germline variation at 8q24 and prostate cancer risk in men of European ancestry

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