Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study
Masahiro Sogabe,1,2 Toshiya Okahisa,1,2 Takeshi Kurihara,2 Miwako Kagawa,2 Kaizo Kagemoto,1 Yoshifumi Kida,1 Tetsu Tomonari,1 Tatsuya Taniguchi,1 Koichi Okamoto,1 Hiroshi Miyamoto,1 Yasushi Sato,1 Masahiko Nakasono,3 Tetsuji Takayama1 1Department of Gastroenterology and Oncology, Tokushima Universit...
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Dove Medical Press
2021
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oai:doaj.org-article:642a268a07644358bc9f42cc539c59a02021-12-02T14:21:25ZDifferences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study1178-7007https://doaj.org/article/642a268a07644358bc9f42cc539c59a02021-04-01T00:00:00Zhttps://www.dovepress.com/differences-in-several-factors-in-the-development-of-erosive-esophagit-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Masahiro Sogabe,1,2 Toshiya Okahisa,1,2 Takeshi Kurihara,2 Miwako Kagawa,2 Kaizo Kagemoto,1 Yoshifumi Kida,1 Tetsu Tomonari,1 Tatsuya Taniguchi,1 Koichi Okamoto,1 Hiroshi Miyamoto,1 Yasushi Sato,1 Masahiko Nakasono,3 Tetsuji Takayama1 1Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan; 2Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Shikokuchuo, Japan; 3Department of Internal Medicine, Tsurugi Municipal Handa Hospital, Tsurugi, JapanCorrespondence: Masahiro SogabeDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima City, Tokushima, 770-8503, JapanTel +81-88-633-7124Fax +81-88-633-9235Email sogabe.masahiro@tokushima-u.ac.jpBackground: Erosive esophagitis (EE) is strongly associated with metabolic syndrome (MS), but is not always recognized in individuals with MS and the prevalence of EE in individuals with non-MS is not low.Aim: To examine the differences in clinical factors associated with EE at various stages of MS, as well as the differences in metabolites between subjects with MS, with and without EE.Methods: A total of 7,097 persons who underwent health checkups including esophagogastroduodenoscopy were analyzed. We examined the differences in clinical factors for EE among subjects with non-MS, pre-MS, and MS and compared metabolites between 34 subjects with MS, with and without EE.Results: EE prevalence was significantly higher in the MS and pre-MS groups than in the non-MS group (p < 0.001). EE severity was higher in the MS group than in the pre-MS and non-MS groups (p < 0.001). In the non-MS group, there were significant differences between subjects with and without EE with respect to Helicobacter pylori (H. pylori) and smoking. In the pre-MS and MS groups, there were significant differences in H. pylori, hiatal hernia, and drinking in those with and without EE. The levels of glutamine, hypoxanthine, and lactic acid metabolites were significantly different between subjects with MS, with and without EE (all p < 0.05).Conclusion: Although H. pylori and lifestyle factors such as smoking and drinking are important for EE, differences in these factors should be considered at various stages of MS. Additionally, several metabolites may be involved in the development of EE in MS.Keywords: metabolic syndrome, erosive esophagitis, metabolite analysisSogabe MOkahisa TKurihara TKagawa MKagemoto KKida YTomonari TTaniguchi TOkamoto KMiyamoto HSato YNakasono MTakayama TDove Medical Pressarticlemetabolic syndromeerosive esophagitismetabolite analysisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1589-1600 (2021) |
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EN |
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metabolic syndrome erosive esophagitis metabolite analysis Specialties of internal medicine RC581-951 |
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metabolic syndrome erosive esophagitis metabolite analysis Specialties of internal medicine RC581-951 Sogabe M Okahisa T Kurihara T Kagawa M Kagemoto K Kida Y Tomonari T Taniguchi T Okamoto K Miyamoto H Sato Y Nakasono M Takayama T Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| description |
Masahiro Sogabe,1,2 Toshiya Okahisa,1,2 Takeshi Kurihara,2 Miwako Kagawa,2 Kaizo Kagemoto,1 Yoshifumi Kida,1 Tetsu Tomonari,1 Tatsuya Taniguchi,1 Koichi Okamoto,1 Hiroshi Miyamoto,1 Yasushi Sato,1 Masahiko Nakasono,3 Tetsuji Takayama1 1Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan; 2Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Shikokuchuo, Japan; 3Department of Internal Medicine, Tsurugi Municipal Handa Hospital, Tsurugi, JapanCorrespondence: Masahiro SogabeDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima City, Tokushima, 770-8503, JapanTel +81-88-633-7124Fax +81-88-633-9235Email sogabe.masahiro@tokushima-u.ac.jpBackground: Erosive esophagitis (EE) is strongly associated with metabolic syndrome (MS), but is not always recognized in individuals with MS and the prevalence of EE in individuals with non-MS is not low.Aim: To examine the differences in clinical factors associated with EE at various stages of MS, as well as the differences in metabolites between subjects with MS, with and without EE.Methods: A total of 7,097 persons who underwent health checkups including esophagogastroduodenoscopy were analyzed. We examined the differences in clinical factors for EE among subjects with non-MS, pre-MS, and MS and compared metabolites between 34 subjects with MS, with and without EE.Results: EE prevalence was significantly higher in the MS and pre-MS groups than in the non-MS group (p < 0.001). EE severity was higher in the MS group than in the pre-MS and non-MS groups (p < 0.001). In the non-MS group, there were significant differences between subjects with and without EE with respect to Helicobacter pylori (H. pylori) and smoking. In the pre-MS and MS groups, there were significant differences in H. pylori, hiatal hernia, and drinking in those with and without EE. The levels of glutamine, hypoxanthine, and lactic acid metabolites were significantly different between subjects with MS, with and without EE (all p < 0.05).Conclusion: Although H. pylori and lifestyle factors such as smoking and drinking are important for EE, differences in these factors should be considered at various stages of MS. Additionally, several metabolites may be involved in the development of EE in MS.Keywords: metabolic syndrome, erosive esophagitis, metabolite analysis |
| format |
article |
| author |
Sogabe M Okahisa T Kurihara T Kagawa M Kagemoto K Kida Y Tomonari T Taniguchi T Okamoto K Miyamoto H Sato Y Nakasono M Takayama T |
| author_facet |
Sogabe M Okahisa T Kurihara T Kagawa M Kagemoto K Kida Y Tomonari T Taniguchi T Okamoto K Miyamoto H Sato Y Nakasono M Takayama T |
| author_sort |
Sogabe M |
| title |
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| title_short |
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| title_full |
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| title_fullStr |
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| title_full_unstemmed |
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study |
| title_sort |
differences in several factors in the development of erosive esophagitis among patients at various stages of metabolic syndrome: a cross-sectional study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/642a268a07644358bc9f42cc539c59a0 |
| work_keys_str_mv |
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