MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors...

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Autores principales:	Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf, David Finkelstein, Geoffrey Neale, Eda Machado, Rosario Mosca, Yvan Campos, Heather Tillman, Martine F. Roussel, Jason Andrew Weesner, Leigh Ellen Fremuth, Xiaohui Qiu, Min-Joon Han, Gerard C. Grosveld, Alessandra d’Azzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
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spelling	oai:doaj.org-article:642d6aea132848be83c0cf12d1e5c4712021-12-02T15:35:17ZMYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat10.1038/s41467-019-11568-02041-1723https://doaj.org/article/642d6aea132848be83c0cf12d1e5c4712019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11568-0https://doaj.org/toc/2041-1723Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors for occupancy of their target gene promoters.Ida AnnunziataDiantha van de VlekkertElmar WolfDavid FinkelsteinGeoffrey NealeEda MachadoRosario MoscaYvan CamposHeather TillmanMartine F. RousselJason Andrew WeesnerLeigh Ellen FremuthXiaohui QiuMin-Joon HanGerard C. GrosveldAlessandra d’AzzoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ida Annunziata Diantha van de Vlekkert Elmar Wolf David Finkelstein Geoffrey Neale Eda Machado Rosario Mosca Yvan Campos Heather Tillman Martine F. Roussel Jason Andrew Weesner Leigh Ellen Fremuth Xiaohui Qiu Min-Joon Han Gerard C. Grosveld Alessandra d’Azzo MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
description	Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors for occupancy of their target gene promoters.
format	article
author	Ida Annunziata Diantha van de Vlekkert Elmar Wolf David Finkelstein Geoffrey Neale Eda Machado Rosario Mosca Yvan Campos Heather Tillman Martine F. Roussel Jason Andrew Weesner Leigh Ellen Fremuth Xiaohui Qiu Min-Joon Han Gerard C. Grosveld Alessandra d’Azzo
author_facet	Ida Annunziata Diantha van de Vlekkert Elmar Wolf David Finkelstein Geoffrey Neale Eda Machado Rosario Mosca Yvan Campos Heather Tillman Martine F. Roussel Jason Andrew Weesner Leigh Ellen Fremuth Xiaohui Qiu Min-Joon Han Gerard C. Grosveld Alessandra d’Azzo
author_sort	Ida Annunziata
title	MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
title_short	MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
title_full	MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
title_fullStr	MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
title_full_unstemmed	MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
title_sort	myc competes with mit/tfe in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
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MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

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