MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf, David Finkelstein, Geoffrey Neale, Eda Machado, Rosario Mosca, Yvan Campos, Heather Tillman, Martine F. Roussel, Jason Andrew Weesner, Leigh Ellen Fremuth, Xiaohui Qiu, Min-Joon Han, Gerard C. Grosveld, Alessandra d’Azzo
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Documents similaires