Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer

Abstract The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Patients were categorized into 2 groups...

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Autores principales:	Yuexiang Liang, Qiang Li, Donglei He, Yong Chen, Jingquan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/642fe3e4fadd4b2fa1a38a5d1f635c23
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spelling	oai:doaj.org-article:642fe3e4fadd4b2fa1a38a5d1f635c232021-12-02T15:08:38ZTumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer10.1038/s41598-021-95828-42045-2322https://doaj.org/article/642fe3e4fadd4b2fa1a38a5d1f635c232021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95828-4https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Patients were categorized into 2 groups according to the best threshold of tumor size: larger group (LG) and smaller group (SG). Propensity score matching was used to adjust for the differences in baseline characteristics. The ideal cutoff point of tumor size was 5 cm. In the multivariate analysis for the whole study series, tumor size was an independent prognostic factor. Patients in the LG had significant lower 5-year overall survival (OS) and relapse-free survival (RFS) rates (OS: 63.5% versus 75.2%, P < 0.001; RFS: 59.5% versus 72.4%, P < 0.001) than those in the SG. After matching, patients in the LG still demonstrated significant lower 5-year OS and RFS rates than those in the SG. The modified tumor-size-node-metastasis (mTSNM) staging system including tumor size was found to be more appropriate for predicting the OS and RFS of T4a stage CC than TNM stage, and the -2log likelihood of the mTSNM staging system was smaller than the value of TNM stage. In conclusion, tumor size was an independent prognostic factor for OS and RFS. We maintain that tumor size should be incorporated into the staging system to enhance the accuracy of the prognostic prediction of T4a stage CC patients.Yuexiang LiangQiang LiDonglei HeYong ChenJingquan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuexiang Liang Qiang Li Donglei He Yong Chen Jingquan Li Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
description	Abstract The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Patients were categorized into 2 groups according to the best threshold of tumor size: larger group (LG) and smaller group (SG). Propensity score matching was used to adjust for the differences in baseline characteristics. The ideal cutoff point of tumor size was 5 cm. In the multivariate analysis for the whole study series, tumor size was an independent prognostic factor. Patients in the LG had significant lower 5-year overall survival (OS) and relapse-free survival (RFS) rates (OS: 63.5% versus 75.2%, P < 0.001; RFS: 59.5% versus 72.4%, P < 0.001) than those in the SG. After matching, patients in the LG still demonstrated significant lower 5-year OS and RFS rates than those in the SG. The modified tumor-size-node-metastasis (mTSNM) staging system including tumor size was found to be more appropriate for predicting the OS and RFS of T4a stage CC than TNM stage, and the -2log likelihood of the mTSNM staging system was smaller than the value of TNM stage. In conclusion, tumor size was an independent prognostic factor for OS and RFS. We maintain that tumor size should be incorporated into the staging system to enhance the accuracy of the prognostic prediction of T4a stage CC patients.
format	article
author	Yuexiang Liang Qiang Li Donglei He Yong Chen Jingquan Li
author_facet	Yuexiang Liang Qiang Li Donglei He Yong Chen Jingquan Li
author_sort	Yuexiang Liang
title	Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
title_short	Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
title_full	Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
title_fullStr	Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
title_full_unstemmed	Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer
title_sort	tumor size improves the accuracy of the prognostic prediction of t4a stage colon cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/642fe3e4fadd4b2fa1a38a5d1f635c23
work_keys_str_mv	AT yuexiangliang tumorsizeimprovestheaccuracyoftheprognosticpredictionoft4astagecoloncancer AT qiangli tumorsizeimprovestheaccuracyoftheprognosticpredictionoft4astagecoloncancer AT dongleihe tumorsizeimprovestheaccuracyoftheprognosticpredictionoft4astagecoloncancer AT yongchen tumorsizeimprovestheaccuracyoftheprognosticpredictionoft4astagecoloncancer AT jingquanli tumorsizeimprovestheaccuracyoftheprognosticpredictionoft4astagecoloncancer
_version_	1718388062537383936

Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer

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