BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.

Guardado en:
Detalles Bibliográficos
Autores principales: Rikke D. Rasmussen, Madhavsai K. Gajjar, Lucie Tuckova, Kamilla E. Jensen, Apolinar Maya-Mendoza, Camilla B. Holst, Kjeld Møllgaard, Jane S. Rasmussen, Jannick Brennum, Jiri Bartek, Martin Syrucek, Eva Sedlakova, Klaus K. Andersen, Marie H. Frederiksen, Petra Hamerlik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6430b3d745974eb39d5f81ae0bb6be25
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6430b3d745974eb39d5f81ae0bb6be25
record_format dspace
spelling oai:doaj.org-article:6430b3d745974eb39d5f81ae0bb6be252021-12-02T16:50:14ZBRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity10.1038/ncomms133982041-1723https://doaj.org/article/6430b3d745974eb39d5f81ae0bb6be252016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13398https://doaj.org/toc/2041-1723BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.Rikke D. RasmussenMadhavsai K. GajjarLucie TuckovaKamilla E. JensenApolinar Maya-MendozaCamilla B. HolstKjeld MøllgaardJane S. RasmussenJannick BrennumJiri BartekMartin SyrucekEva SedlakovaKlaus K. AndersenMarie H. FrederiksenJiri BartekPetra HamerlikNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rikke D. Rasmussen
Madhavsai K. Gajjar
Lucie Tuckova
Kamilla E. Jensen
Apolinar Maya-Mendoza
Camilla B. Holst
Kjeld Møllgaard
Jane S. Rasmussen
Jannick Brennum
Jiri Bartek
Martin Syrucek
Eva Sedlakova
Klaus K. Andersen
Marie H. Frederiksen
Jiri Bartek
Petra Hamerlik
BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
description BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.
format article
author Rikke D. Rasmussen
Madhavsai K. Gajjar
Lucie Tuckova
Kamilla E. Jensen
Apolinar Maya-Mendoza
Camilla B. Holst
Kjeld Møllgaard
Jane S. Rasmussen
Jannick Brennum
Jiri Bartek
Martin Syrucek
Eva Sedlakova
Klaus K. Andersen
Marie H. Frederiksen
Jiri Bartek
Petra Hamerlik
author_facet Rikke D. Rasmussen
Madhavsai K. Gajjar
Lucie Tuckova
Kamilla E. Jensen
Apolinar Maya-Mendoza
Camilla B. Holst
Kjeld Møllgaard
Jane S. Rasmussen
Jannick Brennum
Jiri Bartek
Martin Syrucek
Eva Sedlakova
Klaus K. Andersen
Marie H. Frederiksen
Jiri Bartek
Petra Hamerlik
author_sort Rikke D. Rasmussen
title BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
title_short BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
title_full BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
title_fullStr BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
title_full_unstemmed BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
title_sort brca1-regulated rrm2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6430b3d745974eb39d5f81ae0bb6be25
work_keys_str_mv AT rikkedrasmussen brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT madhavsaikgajjar brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT lucietuckova brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT kamillaejensen brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT apolinarmayamendoza brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT camillabholst brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT kjeldmøllgaard brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT janesrasmussen brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT jannickbrennum brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT jiribartek brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT martinsyrucek brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT evasedlakova brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT klauskandersen brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT mariehfrederiksen brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT jiribartek brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
AT petrahamerlik brca1regulatedrrm2expressionprotectsglioblastomacellsfromendogenousreplicationstressandpromotestumorigenicity
_version_ 1718383041590591488

Ejemplares similares