Convergent allostery in ribonucleotide reductase

Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to capture active and inactive forms of the Bacillus...

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Autores principales:	William C. Thomas, F. Phil Brooks, Audrey A. Burnim, John-Paul Bacik, JoAnne Stubbe, Jason T. Kaelber, James Z. Chen, Nozomi Ando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6430e8e15b544ccd941a8a5b5dbc7669
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spelling	oai:doaj.org-article:6430e8e15b544ccd941a8a5b5dbc76692021-12-02T16:50:58ZConvergent allostery in ribonucleotide reductase10.1038/s41467-019-10568-42041-1723https://doaj.org/article/6430e8e15b544ccd941a8a5b5dbc76692019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10568-4https://doaj.org/toc/2041-1723Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to capture active and inactive forms of the Bacillus subtilis RNR and provide mechanistic insights into a convergent form of allosteric regulation.William C. ThomasF. Phil BrooksAudrey A. BurnimJohn-Paul BacikJoAnne StubbeJason T. KaelberJames Z. ChenNozomi AndoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William C. Thomas F. Phil Brooks Audrey A. Burnim John-Paul Bacik JoAnne Stubbe Jason T. Kaelber James Z. Chen Nozomi Ando Convergent allostery in ribonucleotide reductase
description	Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to capture active and inactive forms of the Bacillus subtilis RNR and provide mechanistic insights into a convergent form of allosteric regulation.
format	article
author	William C. Thomas F. Phil Brooks Audrey A. Burnim John-Paul Bacik JoAnne Stubbe Jason T. Kaelber James Z. Chen Nozomi Ando
author_facet	William C. Thomas F. Phil Brooks Audrey A. Burnim John-Paul Bacik JoAnne Stubbe Jason T. Kaelber James Z. Chen Nozomi Ando
author_sort	William C. Thomas
title	Convergent allostery in ribonucleotide reductase
title_short	Convergent allostery in ribonucleotide reductase
title_full	Convergent allostery in ribonucleotide reductase
title_fullStr	Convergent allostery in ribonucleotide reductase
title_full_unstemmed	Convergent allostery in ribonucleotide reductase
title_sort	convergent allostery in ribonucleotide reductase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6430e8e15b544ccd941a8a5b5dbc7669
work_keys_str_mv	AT williamcthomas convergentallosteryinribonucleotidereductase AT fphilbrooks convergentallosteryinribonucleotidereductase AT audreyaburnim convergentallosteryinribonucleotidereductase AT johnpaulbacik convergentallosteryinribonucleotidereductase AT joannestubbe convergentallosteryinribonucleotidereductase AT jasontkaelber convergentallosteryinribonucleotidereductase AT jameszchen convergentallosteryinribonucleotidereductase AT nozomiando convergentallosteryinribonucleotidereductase
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Convergent allostery in ribonucleotide reductase

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