Network heterogeneity regulates steering in actin-based motility

Protrusive cellular structures contain a heterogeneous density of actin, but whether this influences motility is not known. Using an in vitro system and modelling, here the authors show that local actin monomer depletion and network architecture can tune the rate of network growth to impose steering...

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Autores principales:	Rajaa Boujemaa-Paterski, Cristian Suarez, Tobias Klar, Jie Zhu, Christophe Guérin, Alex Mogilner, Manuel Théry, Laurent Blanchoin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64331f5cf12f4e7b9dc3f3a2a8b59e8b
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spelling	oai:doaj.org-article:64331f5cf12f4e7b9dc3f3a2a8b59e8b2021-12-02T14:42:05ZNetwork heterogeneity regulates steering in actin-based motility10.1038/s41467-017-00455-12041-1723https://doaj.org/article/64331f5cf12f4e7b9dc3f3a2a8b59e8b2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00455-1https://doaj.org/toc/2041-1723Protrusive cellular structures contain a heterogeneous density of actin, but whether this influences motility is not known. Using an in vitro system and modelling, here the authors show that local actin monomer depletion and network architecture can tune the rate of network growth to impose steering during motility.Rajaa Boujemaa-PaterskiCristian SuarezTobias KlarJie ZhuChristophe GuérinAlex MogilnerManuel ThéryLaurent BlanchoinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajaa Boujemaa-Paterski Cristian Suarez Tobias Klar Jie Zhu Christophe Guérin Alex Mogilner Manuel Théry Laurent Blanchoin Network heterogeneity regulates steering in actin-based motility
description	Protrusive cellular structures contain a heterogeneous density of actin, but whether this influences motility is not known. Using an in vitro system and modelling, here the authors show that local actin monomer depletion and network architecture can tune the rate of network growth to impose steering during motility.
format	article
author	Rajaa Boujemaa-Paterski Cristian Suarez Tobias Klar Jie Zhu Christophe Guérin Alex Mogilner Manuel Théry Laurent Blanchoin
author_facet	Rajaa Boujemaa-Paterski Cristian Suarez Tobias Klar Jie Zhu Christophe Guérin Alex Mogilner Manuel Théry Laurent Blanchoin
author_sort	Rajaa Boujemaa-Paterski
title	Network heterogeneity regulates steering in actin-based motility
title_short	Network heterogeneity regulates steering in actin-based motility
title_full	Network heterogeneity regulates steering in actin-based motility
title_fullStr	Network heterogeneity regulates steering in actin-based motility
title_full_unstemmed	Network heterogeneity regulates steering in actin-based motility
title_sort	network heterogeneity regulates steering in actin-based motility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/64331f5cf12f4e7b9dc3f3a2a8b59e8b
work_keys_str_mv	AT rajaaboujemaapaterski networkheterogeneityregulatessteeringinactinbasedmotility AT cristiansuarez networkheterogeneityregulatessteeringinactinbasedmotility AT tobiasklar networkheterogeneityregulatessteeringinactinbasedmotility AT jiezhu networkheterogeneityregulatessteeringinactinbasedmotility AT christopheguerin networkheterogeneityregulatessteeringinactinbasedmotility AT alexmogilner networkheterogeneityregulatessteeringinactinbasedmotility AT manuelthery networkheterogeneityregulatessteeringinactinbasedmotility AT laurentblanchoin networkheterogeneityregulatessteeringinactinbasedmotility
_version_	1718389811426885632

Network heterogeneity regulates steering in actin-based motility

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