Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction

During medical (therapeutic or diagnostic) procedures or in other settings, the circulatory system receives ionizing radiation at various dose rates. Here, we analyzed prelesional changes in the circulatory system of wild-type mice at six months after starting acute, intermittent, or continuous irra...

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Autores principales:	Nobuyuki Hamada, Ki-ichiro Kawano, Takaharu Nomura, Kyoji Furukawa, Farina Mohamad Yusoff, Tatsuya Maruhashi, Makoto Maeda, Ayumu Nakashima, Yukihito Higashi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ionizing radiation aorta vascular damage inflammation intima-media thickening fibrosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/643593e70bc84a74b285249ccf13211f
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spelling	oai:doaj.org-article:643593e70bc84a74b285249ccf13211f2021-11-11T15:28:45ZVascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction10.3390/cancers132153442072-6694https://doaj.org/article/643593e70bc84a74b285249ccf13211f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5344https://doaj.org/toc/2072-6694During medical (therapeutic or diagnostic) procedures or in other settings, the circulatory system receives ionizing radiation at various dose rates. Here, we analyzed prelesional changes in the circulatory system of wild-type mice at six months after starting acute, intermittent, or continuous irradiation with 5 Gy of photons. Independent of irradiation regimens, irradiation had little impact on left ventricular function, heart weight, and kidney weight. In the aorta, a single acute exposure delivered in 10 minutes led to structural disorganizations and detachment of the aortic endothelium, and intima-media thickening. These morphological changes were accompanied by increases in markers for profibrosis (TGF-β1), fibrosis (collagen fibers), proinflammation (TNF-α), and macrophages (F4/80 and CD68), with concurrent decreases in markers for cell adhesion (CD31 and VE-cadherin) and vascular functionality (eNOS) in the aortic endothelium. Compared with acute exposure, the magnitude of such aortic changes was overall greater when the same dose was delivered in 25 fractions spread over 6 weeks, smaller in 100 fractions over 5 months, and much smaller in chronic exposure over 5 months. These findings suggest that dose protraction alters vascular damage in the aorta, but in a way that is not a simple function of dose rate.Nobuyuki HamadaKi-ichiro KawanoTakaharu NomuraKyoji FurukawaFarina Mohamad YusoffTatsuya MaruhashiMakoto MaedaAyumu NakashimaYukihito HigashiMDPI AGarticleionizing radiationaortavascular damageinflammationintima-media thickeningfibrosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5344, p 5344 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ionizing radiation aorta vascular damage inflammation intima-media thickening fibrosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ionizing radiation aorta vascular damage inflammation intima-media thickening fibrosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nobuyuki Hamada Ki-ichiro Kawano Takaharu Nomura Kyoji Furukawa Farina Mohamad Yusoff Tatsuya Maruhashi Makoto Maeda Ayumu Nakashima Yukihito Higashi Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
description	During medical (therapeutic or diagnostic) procedures or in other settings, the circulatory system receives ionizing radiation at various dose rates. Here, we analyzed prelesional changes in the circulatory system of wild-type mice at six months after starting acute, intermittent, or continuous irradiation with 5 Gy of photons. Independent of irradiation regimens, irradiation had little impact on left ventricular function, heart weight, and kidney weight. In the aorta, a single acute exposure delivered in 10 minutes led to structural disorganizations and detachment of the aortic endothelium, and intima-media thickening. These morphological changes were accompanied by increases in markers for profibrosis (TGF-β1), fibrosis (collagen fibers), proinflammation (TNF-α), and macrophages (F4/80 and CD68), with concurrent decreases in markers for cell adhesion (CD31 and VE-cadherin) and vascular functionality (eNOS) in the aortic endothelium. Compared with acute exposure, the magnitude of such aortic changes was overall greater when the same dose was delivered in 25 fractions spread over 6 weeks, smaller in 100 fractions over 5 months, and much smaller in chronic exposure over 5 months. These findings suggest that dose protraction alters vascular damage in the aorta, but in a way that is not a simple function of dose rate.
format	article
author	Nobuyuki Hamada Ki-ichiro Kawano Takaharu Nomura Kyoji Furukawa Farina Mohamad Yusoff Tatsuya Maruhashi Makoto Maeda Ayumu Nakashima Yukihito Higashi
author_facet	Nobuyuki Hamada Ki-ichiro Kawano Takaharu Nomura Kyoji Furukawa Farina Mohamad Yusoff Tatsuya Maruhashi Makoto Maeda Ayumu Nakashima Yukihito Higashi
author_sort	Nobuyuki Hamada
title	Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
title_short	Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
title_full	Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
title_fullStr	Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
title_full_unstemmed	Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction
title_sort	vascular damage in the aorta of wild-type mice exposed to ionizing radiation: sparing and enhancing effects of dose protraction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/643593e70bc84a74b285249ccf13211f
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Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction

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