Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases

Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of...

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Autores principales:	Fatinah Shahab, Inu Mulyantoro, Hary Tjahjanto, Tri Indah Winarni, Sultana MH Faradz
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2021
Materias:	delayed puberty primary amenorrhea cytogenetic. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/643737d8570d47d3a97ce204f9841a66
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spelling	oai:doaj.org-article:643737d8570d47d3a97ce204f9841a662021-11-05T16:47:52ZDelayed Puberty in Girls with Primary Amenorrhea: A Report of Cases2503-217810.14710/jbtr.v7i2.12054https://doaj.org/article/643737d8570d47d3a97ce204f9841a662021-08-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/12054https://doaj.org/toc/2503-2178Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of menses 3 years after the initiation of breast development. Sex chromosomes have an important role in determining the sex, germ cell differentiation of foetus, and reproductive functions of an offspring, thus, sex chromosomal aberrations frequently cause primary amenorrhea Case presentation: We report two delayed puberty cases with the chief complain of primary amenorrhea. Both cases showed hypoplasia of uterus and ovaries on pelvic imaging and hormonal assay showed low of FSH. The first case was gonadal dysgenesis with 46,XX karyotype and low level of estrogen and the second case was a turner syndrome with 45,X karyotype and normal level of estrogen. Conclusion:This study reported delayed puberty with primary amenorrhea cases due to different chromosomal aberration pattern which have similar clinical features. Therefore, cytogenetic examination is needed for any primary amenorrhea cases in order to accomplish the confirmatory diagnosis and for the clinicians to make a correct intervention and treatment.Fatinah ShahabInu MulyantoroHary TjahjantoTri Indah WinarniSultana MH FaradzDiponegoro Universityarticledelayed pubertyprimary amenorrheacytogenetic.Medicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 7, Iss 2, Pp 92-96 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	delayed puberty primary amenorrhea cytogenetic. Medicine (General) R5-920
spellingShingle	delayed puberty primary amenorrhea cytogenetic. Medicine (General) R5-920 Fatinah Shahab Inu Mulyantoro Hary Tjahjanto Tri Indah Winarni Sultana MH Faradz Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
description	Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of menses 3 years after the initiation of breast development. Sex chromosomes have an important role in determining the sex, germ cell differentiation of foetus, and reproductive functions of an offspring, thus, sex chromosomal aberrations frequently cause primary amenorrhea Case presentation: We report two delayed puberty cases with the chief complain of primary amenorrhea. Both cases showed hypoplasia of uterus and ovaries on pelvic imaging and hormonal assay showed low of FSH. The first case was gonadal dysgenesis with 46,XX karyotype and low level of estrogen and the second case was a turner syndrome with 45,X karyotype and normal level of estrogen. Conclusion:This study reported delayed puberty with primary amenorrhea cases due to different chromosomal aberration pattern which have similar clinical features. Therefore, cytogenetic examination is needed for any primary amenorrhea cases in order to accomplish the confirmatory diagnosis and for the clinicians to make a correct intervention and treatment.
format	article
author	Fatinah Shahab Inu Mulyantoro Hary Tjahjanto Tri Indah Winarni Sultana MH Faradz
author_facet	Fatinah Shahab Inu Mulyantoro Hary Tjahjanto Tri Indah Winarni Sultana MH Faradz
author_sort	Fatinah Shahab
title	Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
title_short	Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
title_full	Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
title_fullStr	Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
title_full_unstemmed	Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
title_sort	delayed puberty in girls with primary amenorrhea: a report of cases
publisher	Diponegoro University
publishDate	2021
url	https://doaj.org/article/643737d8570d47d3a97ce204f9841a66
work_keys_str_mv	AT fatinahshahab delayedpubertyingirlswithprimaryamenorrheaareportofcases AT inumulyantoro delayedpubertyingirlswithprimaryamenorrheaareportofcases AT harytjahjanto delayedpubertyingirlswithprimaryamenorrheaareportofcases AT triindahwinarni delayedpubertyingirlswithprimaryamenorrheaareportofcases AT sultanamhfaradz delayedpubertyingirlswithprimaryamenorrheaareportofcases
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Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases

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