Local membrane charge regulates β2 adrenergic receptor coupling to Gi3

In the healthy heart, the β2 adrenergic receptor (β2AR) signals through Gs and Gi proteins but the mechanism underlying G protein selectivity is not fully understood. Here, the authors show that membrane charge and intracellular cations modulate the β2AR−Gi3 interaction.

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Autores principales:	M. J. Strohman, S. Maeda, D. Hilger, M. Masureel, Y. Du, B. K. Kobilka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6438188d5ac44764afe33a71297959d0
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spelling	oai:doaj.org-article:6438188d5ac44764afe33a71297959d02021-12-02T15:35:48ZLocal membrane charge regulates β2 adrenergic receptor coupling to Gi310.1038/s41467-019-10108-02041-1723https://doaj.org/article/6438188d5ac44764afe33a71297959d02019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10108-0https://doaj.org/toc/2041-1723In the healthy heart, the β2 adrenergic receptor (β2AR) signals through Gs and Gi proteins but the mechanism underlying G protein selectivity is not fully understood. Here, the authors show that membrane charge and intracellular cations modulate the β2AR−Gi3 interaction.M. J. StrohmanS. MaedaD. HilgerM. MasureelY. DuB. K. KobilkaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. J. Strohman S. Maeda D. Hilger M. Masureel Y. Du B. K. Kobilka Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
description	In the healthy heart, the β2 adrenergic receptor (β2AR) signals through Gs and Gi proteins but the mechanism underlying G protein selectivity is not fully understood. Here, the authors show that membrane charge and intracellular cations modulate the β2AR−Gi3 interaction.
format	article
author	M. J. Strohman S. Maeda D. Hilger M. Masureel Y. Du B. K. Kobilka
author_facet	M. J. Strohman S. Maeda D. Hilger M. Masureel Y. Du B. K. Kobilka
author_sort	M. J. Strohman
title	Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
title_short	Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
title_full	Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
title_fullStr	Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
title_full_unstemmed	Local membrane charge regulates β2 adrenergic receptor coupling to Gi3
title_sort	local membrane charge regulates β2 adrenergic receptor coupling to gi3
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6438188d5ac44764afe33a71297959d0
work_keys_str_mv	AT mjstrohman localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3 AT smaeda localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3 AT dhilger localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3 AT mmasureel localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3 AT ydu localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3 AT bkkobilka localmembranechargeregulatesb2adrenergicreceptorcouplingtogi3
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Local membrane charge regulates β2 adrenergic receptor coupling to Gi3

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