Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induce...

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Main Authors: Hao Q. Tran, Ruth E. Ley, Andrew T. Gewirtz, Benoit Chassaing
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/643b0d535135477d9cd440f8f3f8075f
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id oai:doaj.org-article:643b0d535135477d9cd440f8f3f8075f
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spelling oai:doaj.org-article:643b0d535135477d9cd440f8f3f8075f2021-12-02T15:36:21ZFlagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases10.1038/s41467-019-13538-y2041-1723https://doaj.org/article/643b0d535135477d9cd440f8f3f8075f2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13538-yhttps://doaj.org/toc/2041-1723Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induced obesity.Hao Q. TranRuth E. LeyAndrew T. GewirtzBenoit ChassaingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hao Q. Tran
Ruth E. Ley
Andrew T. Gewirtz
Benoit Chassaing
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
description Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induced obesity.
format article
author Hao Q. Tran
Ruth E. Ley
Andrew T. Gewirtz
Benoit Chassaing
author_facet Hao Q. Tran
Ruth E. Ley
Andrew T. Gewirtz
Benoit Chassaing
author_sort Hao Q. Tran
title Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
title_short Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
title_full Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
title_fullStr Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
title_full_unstemmed Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
title_sort flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/643b0d535135477d9cd440f8f3f8075f
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AT rutheley flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases
AT andrewtgewirtz flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases
AT benoitchassaing flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases
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