Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induce...
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Nature Portfolio
2019
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oai:doaj.org-article:643b0d535135477d9cd440f8f3f8075f2021-12-02T15:36:21ZFlagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases10.1038/s41467-019-13538-y2041-1723https://doaj.org/article/643b0d535135477d9cd440f8f3f8075f2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13538-yhttps://doaj.org/toc/2041-1723Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induced obesity.Hao Q. TranRuth E. LeyAndrew T. GewirtzBenoit ChassaingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Hao Q. Tran Ruth E. Ley Andrew T. Gewirtz Benoit Chassaing Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
description |
Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induced obesity. |
format |
article |
author |
Hao Q. Tran Ruth E. Ley Andrew T. Gewirtz Benoit Chassaing |
author_facet |
Hao Q. Tran Ruth E. Ley Andrew T. Gewirtz Benoit Chassaing |
author_sort |
Hao Q. Tran |
title |
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
title_short |
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
title_full |
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
title_fullStr |
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
title_full_unstemmed |
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
title_sort |
flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/643b0d535135477d9cd440f8f3f8075f |
work_keys_str_mv |
AT haoqtran flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases AT rutheley flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases AT andrewtgewirtz flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases AT benoitchassaing flagellinelicitedadaptiveimmunitysuppressesflagellatedmicrobiotaandvaccinatesagainstchronicinflammatorydiseases |
_version_ |
1718386291732643840 |